Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1328147..1328727 Replicon chromosome
Accession NZ_CP086832
Organism Pseudosulfitobacter pseudonitzschiae strain TC12-33

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE25_RS06600 Protein ID WP_224556587.1
Coordinates 1328147..1328401 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE25_RS06605 Protein ID WP_224556600.1
Coordinates 1328398..1328727 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE25_RS06545 (LOE25_06530) 1323263..1323652 - 390 WP_224556530.1 hypothetical protein -
LOE25_RS06550 (LOE25_06535) 1323649..1324764 - 1116 WP_224556532.1 hypothetical protein -
LOE25_RS06555 (LOE25_06540) 1324764..1325039 - 276 WP_224556534.1 hypothetical protein -
LOE25_RS06560 (LOE25_06545) 1325110..1325331 - 222 WP_229940865.1 hypothetical protein -
LOE25_RS06565 (LOE25_06550) 1325297..1325581 - 285 WP_229994449.1 hypothetical protein -
LOE25_RS06570 (LOE25_06555) 1325529..1326086 - 558 WP_229994451.1 hypothetical protein -
LOE25_RS06575 (LOE25_06560) 1326064..1326891 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE25_RS06580 (LOE25_06565) 1326888..1327049 - 162 WP_224556578.1 hypothetical protein -
LOE25_RS06585 (LOE25_06570) 1327049..1327501 - 453 WP_224556581.1 hypothetical protein -
LOE25_RS06590 (LOE25_06575) 1327577..1327747 - 171 WP_224556583.1 hypothetical protein -
LOE25_RS06595 (LOE25_06580) 1327847..1328035 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE25_RS06600 (LOE25_06585) 1328147..1328401 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE25_RS06605 (LOE25_06590) 1328398..1328727 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE25_RS06610 (LOE25_06595) 1328788..1329051 + 264 WP_224556602.1 hypothetical protein -
LOE25_RS06615 (LOE25_06600) 1329153..1329443 - 291 WP_224556604.1 hypothetical protein -
LOE25_RS06620 (LOE25_06605) 1329506..1330030 - 525 WP_224556606.1 hypothetical protein -
LOE25_RS06625 (LOE25_06610) 1330250..1330747 - 498 WP_229994453.1 phage minor head protein -
LOE25_RS06630 (LOE25_06615) 1330948..1331694 - 747 WP_224556635.1 hypothetical protein -
LOE25_RS06635 (LOE25_06620) 1331691..1331918 - 228 WP_229940861.1 hypothetical protein -
LOE25_RS06640 (LOE25_06625) 1332571..1333050 - 480 WP_229941854.1 hypothetical protein -
LOE25_RS06645 (LOE25_06630) 1333096..1333527 - 432 WP_224556641.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1319654..1344921 25267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224503 WP_224556587.1 NZ_CP086832:1328147-1328401 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224503 NZ_CP120337:c4666510-4666199 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224503 WP_224556600.1 NZ_CP086832:1328398-1328727 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224503 NZ_CP120337:c4666198-4665908 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References