Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 2526328..2526908 | Replicon | chromosome |
| Accession | NZ_CP086824 | ||
| Organism | Pseudosulfitobacter pseudonitzschiae strain TC12-5 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LOE28_RS12690 | Protein ID | WP_224556587.1 |
| Coordinates | 2526654..2526908 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LOE28_RS12685 | Protein ID | WP_224556600.1 |
| Coordinates | 2526328..2526657 (-) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOE28_RS12630 (LOE28_12645) | 2521400..2522290 | + | 891 | WP_229940766.1 | RNA ligase family protein | - |
| LOE28_RS12635 (LOE28_12650) | 2522290..2522478 | + | 189 | WP_224556628.1 | hypothetical protein | - |
| LOE28_RS12640 (LOE28_12655) | 2522475..2522633 | + | 159 | WP_224556625.1 | hypothetical protein | - |
| LOE28_RS12645 (LOE28_12660) | 2522630..2522884 | + | 255 | WP_224556623.1 | hypothetical protein | - |
| LOE28_RS12650 (LOE28_12665) | 2522881..2523186 | + | 306 | WP_224556620.1 | helix-turn-helix domain-containing protein | - |
| LOE28_RS12655 (LOE28_12670) | 2523183..2523599 | + | 417 | WP_229940505.1 | hypothetical protein | - |
| LOE28_RS12660 (LOE28_12675) | 2523596..2523760 | + | 165 | WP_229940508.1 | hypothetical protein | - |
| LOE28_RS12665 (LOE28_12680) | 2523882..2524805 | + | 924 | WP_229940510.1 | phage minor head protein | - |
| LOE28_RS12670 (LOE28_12685) | 2525025..2525549 | + | 525 | WP_224556606.1 | hypothetical protein | - |
| LOE28_RS12675 (LOE28_12690) | 2525612..2525902 | + | 291 | WP_224556604.1 | hypothetical protein | - |
| LOE28_RS24910 | 2525895..2526017 | + | 123 | WP_263481010.1 | hypothetical protein | - |
| LOE28_RS12680 (LOE28_12695) | 2526004..2526267 | - | 264 | WP_224556602.1 | hypothetical protein | - |
| LOE28_RS12685 (LOE28_12700) | 2526328..2526657 | - | 330 | WP_224556600.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LOE28_RS12690 (LOE28_12705) | 2526654..2526908 | - | 255 | WP_224556587.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LOE28_RS12695 (LOE28_12710) | 2527020..2527208 | - | 189 | WP_224556585.1 | ribbon-helix-helix domain-containing protein | - |
| LOE28_RS12700 (LOE28_12715) | 2527308..2527478 | + | 171 | WP_224556583.1 | hypothetical protein | - |
| LOE28_RS12705 (LOE28_12720) | 2527554..2528006 | + | 453 | WP_224556581.1 | hypothetical protein | - |
| LOE28_RS12710 (LOE28_12725) | 2528006..2528167 | + | 162 | WP_224556578.1 | hypothetical protein | - |
| LOE28_RS12715 (LOE28_12730) | 2528164..2528991 | + | 828 | WP_224556575.1 | ParB N-terminal domain-containing protein | - |
| LOE28_RS12720 (LOE28_12735) | 2528969..2529484 | + | 516 | WP_224556573.1 | hypothetical protein | - |
| LOE28_RS12725 (LOE28_12740) | 2529562..2529885 | - | 324 | WP_224556571.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2508527..2545148 | 36621 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9336.69 Da Isoelectric Point: 10.8025
>T224498 WP_224556587.1 NZ_CP086824:c2526908-2526654 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP
Download Length: 255 bp
>T224498 NZ_CP120337:2101792-2101895 [Salmonella enterica subsp. enterica serovar Muenchen]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 110 a.a. Molecular weight: 12090.66 Da Isoelectric Point: 6.0876
>AT224498 WP_224556600.1 NZ_CP086824:c2526657-2526328 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH
Download Length: 330 bp
>AT224498 NZ_CP120337:c2101897-2101752 [Salmonella enterica subsp. enterica serovar Muenchen]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|