Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 545191..545656 Replicon chromosome
Accession NZ_CP086824
Organism Pseudosulfitobacter pseudonitzschiae strain TC12-5

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LOE28_RS02545 Protein ID WP_224557762.1
Coordinates 545393..545656 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LOE28_RS02540 Protein ID WP_224557764.1
Coordinates 545191..545406 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE28_RS02505 (LOE28_02510) 540299..540664 + 366 WP_028957811.1 cytochrome o ubiquinol oxidase subunit IV -
LOE28_RS02510 (LOE28_02515) 540661..541359 + 699 WP_037931342.1 SURF1 family protein -
LOE28_RS02520 (LOE28_02525) 541737..542921 + 1185 WP_224557768.1 site-specific integrase -
LOE28_RS02525 (LOE28_02530) 542914..543885 + 972 WP_224557767.1 hypothetical protein -
LOE28_RS02530 (LOE28_02535) 544066..544446 + 381 WP_224557766.1 helix-turn-helix domain-containing protein -
LOE28_RS02535 (LOE28_02540) 544614..544838 + 225 WP_224557765.1 hypothetical protein -
LOE28_RS02540 (LOE28_02545) 545191..545406 - 216 WP_224557764.1 CopG family antitoxin Antitoxin
LOE28_RS02545 (LOE28_02550) 545393..545656 - 264 WP_224557762.1 BrnT family toxin Toxin
LOE28_RS02550 (LOE28_02555) 545844..546287 + 444 WP_224557760.1 hypothetical protein -
LOE28_RS02555 (LOE28_02560) 546380..547489 + 1110 WP_224558030.1 IS110 family transposase -
LOE28_RS02560 (LOE28_02565) 547715..548203 + 489 WP_229938596.1 DEAD/DEAH box helicase family protein -
LOE28_RS02565 (LOE28_02570) 548127..548393 + 267 WP_229938971.1 type I restriction-modification enzyme R subunit C-terminal domain-containing protein -
LOE28_RS02570 (LOE28_02575) 548390..549940 + 1551 WP_224557015.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 543091..554250 11159


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10254.52 Da        Isoelectric Point: 5.6550

>T224497 WP_224557762.1 NZ_CP086824:c545656-545393 [Pseudosulfitobacter pseudonitzschiae]
MKFEYDPDKSAGNKAKHGIDFDEAQALWEDPWLLEAPARTDDEPRFFAIGMIKERHWSAVCTYRGDIIRIISVRRARKQE
IEHYEST

Download         Length: 264 bp

>T224497 NZ_CP120337:c1017839-1017312 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8265.40 Da        Isoelectric Point: 10.6538

>AT224497 WP_224557764.1 NZ_CP086824:c545406-545191 [Pseudosulfitobacter pseudonitzschiae]
MKAREFDQKFDTGENVSDLVDWSKARRTNTQTKRVNVDFPSWVVSGLDQKAKQLGVTRQSLIKLWIAERLQ

Download         Length: 216 bp

>AT224497 NZ_CP120337:c1018126-1017836 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References