Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 25993..26554 Replicon plasmid P7
Accession NZ_CP086823
Organism Pseudosulfitobacter pseudonitzschiae strain TC12-52

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LOE26_RS24535 Protein ID WP_224557555.1
Coordinates 26279..26554 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LOE26_RS24530 Protein ID WP_224557554.1
Coordinates 25993..26286 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE26_RS24515 (LOE26_24510) 21470..23005 - 1536 WP_224557548.1 aldehyde dehydrogenase (NADP(+)) -
LOE26_RS24520 (LOE26_24515) 23267..25006 + 1740 WP_224557550.1 L-arabinonate dehydratase -
LOE26_RS24525 (LOE26_24520) 25017..25922 + 906 WP_224557552.1 dihydrodipicolinate synthase family protein -
LOE26_RS24530 (LOE26_24525) 25993..26286 + 294 WP_224557554.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LOE26_RS24535 (LOE26_24530) 26279..26554 + 276 WP_224557555.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOE26_RS24540 (LOE26_24535) 27023..27793 - 771 WP_224557557.1 GntR family transcriptional regulator -
LOE26_RS24545 (LOE26_24540) 27885..29432 + 1548 WP_224557559.1 altronate dehydratase family protein -
LOE26_RS24550 (LOE26_24545) 29449..30765 + 1317 WP_224557560.1 lactate racemase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..82375 82375


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-55)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10108.67 Da        Isoelectric Point: 4.4912

>T224496 WP_224557555.1 NZ_CP086823:26279-26554 [Pseudosulfitobacter pseudonitzschiae]
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP

Download         Length: 276 bp

>T224496 NZ_CP120337:854957-855370 [Salmonella enterica subsp. enterica serovar Muenchen]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTAATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGTTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10166.59 Da        Isoelectric Point: 7.2024

>AT224496 WP_224557554.1 NZ_CP086823:25993-26286 [Pseudosulfitobacter pseudonitzschiae]
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA

Download         Length: 294 bp

>AT224496 NZ_CP120337:854710-854976 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References