Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2590871..2591451 Replicon chromosome
Accession NZ_CP086816
Organism Pseudosulfitobacter pseudonitzschiae strain TC12-52

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE26_RS12575 Protein ID WP_224556587.1
Coordinates 2590871..2591125 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE26_RS12580 Protein ID WP_224556600.1
Coordinates 2591122..2591451 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE26_RS12540 (LOE26_12540) 2587894..2588217 + 324 WP_224556571.1 hypothetical protein -
LOE26_RS12545 (LOE26_12545) 2588295..2588810 - 516 WP_224556573.1 hypothetical protein -
LOE26_RS12550 (LOE26_12550) 2588788..2589615 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE26_RS12555 (LOE26_12555) 2589612..2589773 - 162 WP_224556578.1 hypothetical protein -
LOE26_RS12560 (LOE26_12560) 2589773..2590225 - 453 WP_224556581.1 hypothetical protein -
LOE26_RS12565 (LOE26_12565) 2590301..2590471 - 171 WP_224556583.1 hypothetical protein -
LOE26_RS12570 (LOE26_12570) 2590571..2590759 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE26_RS12575 (LOE26_12575) 2590871..2591125 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE26_RS12580 (LOE26_12580) 2591122..2591451 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE26_RS12585 (LOE26_12585) 2591512..2591775 + 264 WP_224556602.1 hypothetical protein -
LOE26_RS24780 2591762..2591884 - 123 WP_263481010.1 hypothetical protein -
LOE26_RS12590 (LOE26_12590) 2591877..2592167 - 291 WP_224556604.1 hypothetical protein -
LOE26_RS12595 (LOE26_12595) 2592230..2592754 - 525 WP_224556606.1 hypothetical protein -
LOE26_RS12600 (LOE26_12600) 2592974..2593897 - 924 WP_229940510.1 phage minor head protein -
LOE26_RS12605 (LOE26_12605) 2594019..2594183 - 165 WP_229940508.1 hypothetical protein -
LOE26_RS12610 (LOE26_12610) 2594180..2594596 - 417 WP_229940505.1 hypothetical protein -
LOE26_RS12615 (LOE26_12615) 2594593..2594898 - 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE26_RS12620 (LOE26_12620) 2594895..2595149 - 255 WP_224556623.1 hypothetical protein -
LOE26_RS12625 (LOE26_12625) 2595146..2595304 - 159 WP_224556625.1 hypothetical protein -
LOE26_RS12630 (LOE26_12630) 2595301..2595489 - 189 WP_224556628.1 hypothetical protein -
LOE26_RS12635 (LOE26_12635) 2595489..2596376 - 888 WP_224556631.1 RNA ligase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2573179..2610692 37513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224491 WP_224556587.1 NZ_CP086816:2590871-2591125 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224491 NZ_CP120336:14790-15122 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTACTTAT
CGTTTCTCCGGCATCATTTAATAAGTTCACCCGGTTACCCGTTGTCGTTCCCGTCACCAGCGGCGGAGACTTTGCCCGCA
CAGCCGGTTTTACCGTCTCCCTGGACGGCGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAGCCCAGAACGATT
GATATGGGTGCCCGGAATGGTAAGCGTCTGGAACGTATACCCGAAGCTGTCGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224491 WP_224556600.1 NZ_CP086816:2591122-2591451 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224491 NZ_CP120336:14532-14789 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGCTCT
GTCGACAGACAGCGAAGTGGGAATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCACAGTGCGATCCGCACGCCGAAATGAGCGATGAGGATAGGGAATGGATGGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References