Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 48095..48656 Replicon plasmid P6
Accession NZ_CP086814
Organism Pseudosulfitobacter pseudonitzschiae strain TC12-54

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LOE27_RS23780 Protein ID WP_224557555.1
Coordinates 48095..48370 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LOE27_RS23785 Protein ID WP_224557554.1
Coordinates 48363..48656 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE27_RS23765 (LOE27_23745) 43884..45200 - 1317 WP_224557560.1 lactate racemase domain-containing protein -
LOE27_RS23770 (LOE27_23750) 45217..46764 - 1548 WP_224557559.1 altronate dehydratase family protein -
LOE27_RS23775 (LOE27_23755) 46856..47626 + 771 WP_224557557.1 GntR family transcriptional regulator -
LOE27_RS23780 (LOE27_23760) 48095..48370 - 276 WP_224557555.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOE27_RS23785 (LOE27_23765) 48363..48656 - 294 WP_224557554.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LOE27_RS23790 (LOE27_23770) 48727..49632 - 906 WP_224557552.1 dihydrodipicolinate synthase family protein -
LOE27_RS23795 (LOE27_23775) 49643..51382 - 1740 WP_224557550.1 L-arabinonate dehydratase -
LOE27_RS23800 (LOE27_23780) 51644..53179 + 1536 WP_224557548.1 aldehyde dehydrogenase (NADP(+)) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..82232 82232


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-55)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10108.67 Da        Isoelectric Point: 4.4912

>T224488 WP_224557555.1 NZ_CP086814:c48370-48095 [Pseudosulfitobacter pseudonitzschiae]
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP

Download         Length: 276 bp

>T224488 NZ_CP120335:c4216665-4216381 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10166.59 Da        Isoelectric Point: 7.2024

>AT224488 WP_224557554.1 NZ_CP086814:c48656-48363 [Pseudosulfitobacter pseudonitzschiae]
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA

Download         Length: 294 bp

>AT224488 NZ_CP120335:c4216897-4216655 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References