Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 2064678..2065258 | Replicon | chromosome |
| Accession | NZ_CP086808 | ||
| Organism | Pseudosulfitobacter pseudonitzschiae strain TC12-54 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LOE27_RS10560 | Protein ID | WP_224556587.1 |
| Coordinates | 2065004..2065258 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LOE27_RS10555 | Protein ID | WP_224556600.1 |
| Coordinates | 2064678..2065007 (-) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOE27_RS10515 (LOE27_10505) | 2059878..2060309 | + | 432 | WP_224556641.1 | hypothetical protein | - |
| LOE27_RS10520 (LOE27_10510) | 2060355..2060834 | + | 480 | WP_229941854.1 | hypothetical protein | - |
| LOE27_RS10525 (LOE27_10515) | 2061487..2061714 | + | 228 | WP_229940861.1 | hypothetical protein | - |
| LOE27_RS10530 (LOE27_10520) | 2061711..2062457 | + | 747 | WP_224556635.1 | hypothetical protein | - |
| LOE27_RS10535 (LOE27_10525) | 2062658..2063155 | + | 498 | WP_229994453.1 | phage minor head protein | - |
| LOE27_RS10540 (LOE27_10530) | 2063375..2063899 | + | 525 | WP_224556606.1 | hypothetical protein | - |
| LOE27_RS10545 (LOE27_10535) | 2063962..2064252 | + | 291 | WP_224556604.1 | hypothetical protein | - |
| LOE27_RS24130 | 2064245..2064367 | + | 123 | WP_263481010.1 | hypothetical protein | - |
| LOE27_RS10550 (LOE27_10540) | 2064354..2064617 | - | 264 | WP_224556602.1 | hypothetical protein | - |
| LOE27_RS10555 (LOE27_10545) | 2064678..2065007 | - | 330 | WP_224556600.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LOE27_RS10560 (LOE27_10550) | 2065004..2065258 | - | 255 | WP_224556587.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LOE27_RS10565 (LOE27_10555) | 2065370..2065558 | - | 189 | WP_224556585.1 | ribbon-helix-helix domain-containing protein | - |
| LOE27_RS10570 (LOE27_10560) | 2065658..2065828 | + | 171 | WP_224556583.1 | hypothetical protein | - |
| LOE27_RS10575 (LOE27_10565) | 2065904..2066356 | + | 453 | WP_224556581.1 | hypothetical protein | - |
| LOE27_RS10580 (LOE27_10570) | 2066356..2066517 | + | 162 | WP_224556578.1 | hypothetical protein | - |
| LOE27_RS10585 (LOE27_10575) | 2066514..2067341 | + | 828 | WP_224556575.1 | ParB N-terminal domain-containing protein | - |
| LOE27_RS10590 (LOE27_10580) | 2067319..2067876 | + | 558 | WP_229994451.1 | hypothetical protein | - |
| LOE27_RS10595 (LOE27_10585) | 2067854..2068108 | + | 255 | WP_229997190.1 | hypothetical protein | - |
| LOE27_RS10600 (LOE27_10590) | 2068071..2068295 | + | 225 | WP_224556537.1 | hypothetical protein | - |
| LOE27_RS10605 (LOE27_10595) | 2068366..2068641 | + | 276 | WP_224556534.1 | hypothetical protein | - |
| LOE27_RS10610 (LOE27_10600) | 2068641..2069756 | + | 1116 | WP_224556532.1 | hypothetical protein | - |
| LOE27_RS10615 (LOE27_10605) | 2069753..2070142 | + | 390 | WP_224556530.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2049924..2074299 | 24375 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9336.69 Da Isoelectric Point: 10.8025
>T224484 WP_224556587.1 NZ_CP086808:c2065258-2065004 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP
Download Length: 255 bp
>T224484 NZ_CP120335:2101635-2101738 [Salmonella enterica subsp. enterica serovar Muenchen]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 110 a.a. Molecular weight: 12090.66 Da Isoelectric Point: 6.0876
>AT224484 WP_224556600.1 NZ_CP086808:c2065007-2064678 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH
Download Length: 330 bp
>AT224484 NZ_CP120335:c2101740-2101595 [Salmonella enterica subsp. enterica serovar Muenchen]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|