Detailed information of TA system TA224475

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 31259..31820
• Replicon: plasmid P7
• Accession: NZ_CP086797
• Organism: Pseudosulfitobacter pseudonitzschiae strain TT37-67

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOE38_RS24305
• Protein ID: WP_224557555.1
• Coordinates: 31259..31534 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LOE38_RS24310
• Protein ID: WP_224557554.1
• Coordinates: 31527..31820 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOE38_RS24290 (LOE38_24270)	27048..28364	-	1317	WP_224557560.1	lactate racemase domain-containing protein	-
LOE38_RS24295 (LOE38_24275)	28381..29928	-	1548	WP_224557559.1	altronate dehydratase family protein	-
LOE38_RS24300 (LOE38_24280)	30020..30790	+	771	WP_224557557.1	GntR family transcriptional regulator	-
LOE38_RS24305 (LOE38_24285)	31259..31534	-	276	WP_224557555.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOE38_RS24310 (LOE38_24290)	31527..31820	-	294	WP_224557554.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LOE38_RS24315 (LOE38_24295)	31891..32796	-	906	WP_224557552.1	dihydrodipicolinate synthase family protein	-
LOE38_RS24320 (LOE38_24300)	32807..34546	-	1740	WP_224557550.1	L-arabinonate dehydratase	-
LOE38_RS24325 (LOE38_24305)	34808..36343	+	1536	WP_224557548.1	aldehyde dehydrogenase (NADP(+))	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..82228	82228

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-55)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10108.67 Da
• Isoelectric Point: 4.4912

>T224475 WP_224557555.1 NZ_CP086797:c31534-31259 [Pseudosulfitobacter pseudonitzschiae]
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP

Nucleotide

• Length: 276 bp

>T224475 NZ_CP120333:c4666511-4666200 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10166.59 Da
• Isoelectric Point: 7.2024

>AT224475 WP_224557554.1 NZ_CP086797:c31820-31527 [Pseudosulfitobacter pseudonitzschiae]
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA

Nucleotide

• Length: 294 bp

>AT224475 NZ_CP120333:c4666199-4665909 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA