Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 148599..149273 Replicon plasmid P6
Accession NZ_CP086796
Organism Pseudosulfitobacter pseudonitzschiae strain TT37-67

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE38_RS23505 Protein ID WP_224557924.1
Coordinates 148599..149021 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE38_RS23510 Protein ID WP_229939240.1
Coordinates 149025..149273 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE38_RS23495 (LOE38_23480) 144797..145855 - 1059 WP_224557922.1 HEPN domain-containing protein -
LOE38_RS23500 (LOE38_23485) 145852..148602 - 2751 WP_224557923.1 lactate dehydrogenase -
LOE38_RS23505 (LOE38_23490) 148599..149021 - 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE38_RS23510 (LOE38_23495) 149025..149273 - 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE38_RS23515 (LOE38_23500) 149421..150410 - 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE38_RS23520 (LOE38_23505) 150521..151978 - 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE38_RS23525 (LOE38_23510) 151981..152712 - 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE38_RS23530 (LOE38_23515) 152716..153360 - 645 WP_224557929.1 type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..290596 290596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224474 WP_224557924.1 NZ_CP086796:c149021-148599 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224474 NZ_CP120333:c4216824-4216540 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224474 WP_229939240.1 NZ_CP086796:c149273-149025 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224474 NZ_CP120333:c4217056-4216814 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References