Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2523582..2524162 Replicon chromosome
Accession NZ_CP086790
Organism Pseudosulfitobacter pseudonitzschiae strain TT37-67

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE38_RS12670 Protein ID WP_224556587.1
Coordinates 2523908..2524162 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE38_RS12665 Protein ID WP_224556600.1
Coordinates 2523582..2523911 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE38_RS12610 (LOE38_12600) 2518657..2519544 + 888 WP_224556631.1 RNA ligase family protein -
LOE38_RS12615 (LOE38_12605) 2519544..2519732 + 189 WP_224556628.1 hypothetical protein -
LOE38_RS12620 (LOE38_12610) 2519729..2519887 + 159 WP_224556625.1 hypothetical protein -
LOE38_RS12625 (LOE38_12615) 2519884..2520138 + 255 WP_224556623.1 hypothetical protein -
LOE38_RS12630 (LOE38_12620) 2520135..2520440 + 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE38_RS12635 (LOE38_12625) 2520437..2520853 + 417 WP_229940505.1 hypothetical protein -
LOE38_RS12640 (LOE38_12630) 2520850..2521014 + 165 WP_229940508.1 hypothetical protein -
LOE38_RS12645 (LOE38_12635) 2521136..2522059 + 924 WP_229940510.1 phage minor head protein -
LOE38_RS12650 (LOE38_12640) 2522279..2522803 + 525 WP_224556606.1 hypothetical protein -
LOE38_RS12655 (LOE38_12645) 2522866..2523156 + 291 WP_224556604.1 hypothetical protein -
LOE38_RS24540 2523149..2523271 + 123 WP_263481010.1 hypothetical protein -
LOE38_RS12660 (LOE38_12650) 2523258..2523521 - 264 WP_224556602.1 hypothetical protein -
LOE38_RS12665 (LOE38_12655) 2523582..2523911 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE38_RS12670 (LOE38_12660) 2523908..2524162 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE38_RS12675 (LOE38_12665) 2524274..2524462 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE38_RS12680 (LOE38_12670) 2524562..2524732 + 171 WP_224556583.1 hypothetical protein -
LOE38_RS12685 (LOE38_12675) 2524808..2525260 + 453 WP_224556581.1 hypothetical protein -
LOE38_RS12690 (LOE38_12680) 2525260..2525421 + 162 WP_224556578.1 hypothetical protein -
LOE38_RS12695 (LOE38_12685) 2525418..2526245 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE38_RS12700 (LOE38_12690) 2526223..2526738 + 516 WP_224556573.1 hypothetical protein -
LOE38_RS12705 (LOE38_12695) 2526816..2527139 - 324 WP_224556571.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2505781..2542402 36621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224469 WP_224556587.1 NZ_CP086790:c2524162-2523908 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224469 NZ_CP120333:c1017845-1017318 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224469 WP_224556600.1 NZ_CP086790:c2523911-2523582 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224469 NZ_CP120333:c1018132-1017842 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References