Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 39423..39984 Replicon plasmid P6
Accession NZ_CP086789
Organism Pseudosulfitobacter pseudonitzschiae strain TT37-68

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LOE39_RS22990 Protein ID WP_224557555.1
Coordinates 39709..39984 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LOE39_RS22985 Protein ID WP_224557554.1
Coordinates 39423..39716 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE39_RS22970 (LOE39_22960) 34900..36435 - 1536 WP_224557548.1 aldehyde dehydrogenase (NADP(+)) -
LOE39_RS22975 (LOE39_22965) 36697..38436 + 1740 WP_224557550.1 L-arabinonate dehydratase -
LOE39_RS22980 (LOE39_22970) 38447..39352 + 906 WP_224557552.1 dihydrodipicolinate synthase family protein -
LOE39_RS22985 (LOE39_22975) 39423..39716 + 294 WP_224557554.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LOE39_RS22990 (LOE39_22980) 39709..39984 + 276 WP_224557555.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOE39_RS22995 (LOE39_22985) 40453..41223 - 771 WP_224557557.1 GntR family transcriptional regulator -
LOE39_RS23000 (LOE39_22990) 41315..42862 + 1548 WP_224557559.1 altronate dehydratase family protein -
LOE39_RS23005 (LOE39_22995) 42879..44195 + 1317 WP_224557560.1 lactate racemase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..82233 82233


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-55)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10108.67 Da        Isoelectric Point: 4.4912

>T224467 WP_224557555.1 NZ_CP086789:39709-39984 [Pseudosulfitobacter pseudonitzschiae]
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP

Download         Length: 276 bp

>T224467 NZ_CP120333:311879-312247 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10166.59 Da        Isoelectric Point: 7.2024

>AT224467 WP_224557554.1 NZ_CP086789:39423-39716 [Pseudosulfitobacter pseudonitzschiae]
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA

Download         Length: 294 bp

>AT224467 NZ_CP120333:311661-311882 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References