Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2520925..2521505 Replicon chromosome
Accession NZ_CP086783
Organism Pseudosulfitobacter pseudonitzschiae strain TT37-68

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE39_RS12660 Protein ID WP_224556587.1
Coordinates 2521251..2521505 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE39_RS12655 Protein ID WP_224556600.1
Coordinates 2520925..2521254 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE39_RS12600 (LOE39_12600) 2516186..2516887 + 702 WP_229940503.1 RNA ligase family protein -
LOE39_RS12605 (LOE39_12605) 2516887..2517075 + 189 WP_224556628.1 hypothetical protein -
LOE39_RS12610 (LOE39_12610) 2517072..2517230 + 159 WP_224556625.1 hypothetical protein -
LOE39_RS12615 (LOE39_12615) 2517227..2517481 + 255 WP_224556623.1 hypothetical protein -
LOE39_RS12620 (LOE39_12620) 2517478..2517783 + 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE39_RS12625 (LOE39_12625) 2517780..2518196 + 417 WP_229940505.1 hypothetical protein -
LOE39_RS12630 (LOE39_12630) 2518193..2518357 + 165 WP_229940508.1 hypothetical protein -
LOE39_RS12635 (LOE39_12635) 2518479..2519402 + 924 WP_229940510.1 phage minor head protein -
LOE39_RS12640 (LOE39_12640) 2519622..2520146 + 525 WP_224556606.1 hypothetical protein -
LOE39_RS12645 (LOE39_12645) 2520209..2520499 + 291 WP_224556604.1 hypothetical protein -
LOE39_RS23180 2520492..2520614 + 123 WP_263481010.1 hypothetical protein -
LOE39_RS12650 (LOE39_12650) 2520601..2520864 - 264 WP_224556602.1 hypothetical protein -
LOE39_RS12655 (LOE39_12655) 2520925..2521254 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE39_RS12660 (LOE39_12660) 2521251..2521505 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE39_RS12665 (LOE39_12665) 2521617..2521805 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE39_RS12670 (LOE39_12670) 2521905..2522075 + 171 WP_224556583.1 hypothetical protein -
LOE39_RS12675 (LOE39_12675) 2522151..2522603 + 453 WP_224556581.1 hypothetical protein -
LOE39_RS12680 (LOE39_12680) 2522603..2522764 + 162 WP_224556578.1 hypothetical protein -
LOE39_RS12685 (LOE39_12685) 2522761..2523588 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE39_RS12690 (LOE39_12690) 2523566..2524081 + 516 WP_224556573.1 hypothetical protein -
LOE39_RS12695 (LOE39_12695) 2524159..2524482 - 324 WP_224556571.1 hypothetical protein -
LOE39_RS12700 (LOE39_12700) 2524697..2525239 - 543 WP_229940519.1 hypothetical protein -
LOE39_RS12705 (LOE39_12705) 2525802..2526050 - 249 WP_229940863.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2505779..2539745 33966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224463 WP_224556587.1 NZ_CP086783:c2521505-2521251 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224463 NZ_CP120332:14788-15120 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTACTTAT
CGTTTCTCCGGCATCATTTAATAAGTTCACCCGGTTACCCGTTGTCGTTCCCGTCACCAGCGGCGGAGACTTTGCCCGCA
CAGCCGGTTTTACCGTCTCCCTGGACGGCGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAGCCCAGAACGATT
GATATGGGTGCCCGGAATGGTAAGCGTCTGGAACGTATACCCGAAGCTGTCGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224463 WP_224556600.1 NZ_CP086783:c2521254-2520925 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224463 NZ_CP120332:14530-14787 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGCTCT
GTCGACAGACAGCGAAGTGGGAATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCACAGTGCGATCCGCACGCCGAAATGAGCGATGAGGATAGGGAATGGATGGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References