Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 86719..87331 Replicon plasmid P4
Accession NZ_CP086779
Organism Pseudosulfitobacter pseudonitzschiae strain TT37-69

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE40_RS21475 Protein ID WP_028288627.1
Coordinates 86719..87114 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE40_RS21480 Protein ID WP_009503866.1
Coordinates 87104..87331 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE40_RS21455 (LOE40_21415) 83238..83849 - 612 WP_197919471.1 SMC-Scp complex subunit ScpB -
LOE40_RS21460 (LOE40_21420) 83897..84781 - 885 WP_229997765.1 DUF1403 family protein -
LOE40_RS21465 (LOE40_21425) 84908..86047 + 1140 WP_229940649.1 tyrosine-type recombinase/integrase -
LOE40_RS21470 (LOE40_21430) 86149..86640 + 492 Protein_89 recombinase family protein -
LOE40_RS21475 (LOE40_21435) 86719..87114 - 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE40_RS21480 (LOE40_21440) 87104..87331 - 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE40_RS21485 (LOE40_21445) 87540..88733 + 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE40_RS21490 (LOE40_21450) 88717..89649 + 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE40_RS21495 (LOE40_21455) 89863..91074 + 1212 WP_050525470.1 plasmid replication protein RepC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110559 110559


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224460 WP_028288627.1 NZ_CP086779:c87114-86719 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224460 NZ_CP120331:c4216824-4216540 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224460 WP_009503866.1 NZ_CP086779:c87331-87104 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224460 NZ_CP120331:c4217056-4216814 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References