Detailed information of TA system TA224455

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 70405..70966
• Replicon: plasmid P8
• Accession: NZ_CP086772
• Organism: Pseudosulfitobacter pseudonitzschiae strain TT37-74

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOE41_RS24105
• Protein ID: WP_224557555.1
• Coordinates: 70405..70680 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LOE41_RS24110
• Protein ID: WP_224557554.1
• Coordinates: 70673..70966 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOE41_RS24090 (LOE41_24080)	66194..67510	-	1317	WP_224557560.1	lactate racemase domain-containing protein	-
LOE41_RS24095 (LOE41_24085)	67527..69074	-	1548	WP_224557559.1	altronate dehydratase family protein	-
LOE41_RS24100 (LOE41_24090)	69199..69936	+	738	WP_229940771.1	GntR family transcriptional regulator	-
LOE41_RS24105 (LOE41_24095)	70405..70680	-	276	WP_224557555.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOE41_RS24110 (LOE41_24100)	70673..70966	-	294	WP_224557554.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LOE41_RS24115 (LOE41_24105)	71037..71942	-	906	WP_224557552.1	dihydrodipicolinate synthase family protein	-
LOE41_RS24120 (LOE41_24110)	71953..73692	-	1740	WP_224557550.1	L-arabinonate dehydratase	-
LOE41_RS24125 (LOE41_24115)	73954..75489	+	1536	WP_224557548.1	aldehyde dehydrogenase (NADP(+))	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..82231	82231

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-55)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10108.67 Da
• Isoelectric Point: 4.4912

>T224455 WP_224557555.1 NZ_CP086772:c70680-70405 [Pseudosulfitobacter pseudonitzschiae]
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP

Nucleotide

• Length: 276 bp

>T224455 NZ_CP120331:c1017839-1017312 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10166.59 Da
• Isoelectric Point: 7.2024

>AT224455 WP_224557554.1 NZ_CP086772:c70966-70673 [Pseudosulfitobacter pseudonitzschiae]
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA

Nucleotide

• Length: 294 bp

>AT224455 NZ_CP120331:c1018126-1017836 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA