Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 80944..81618 Replicon plasmid P5
Accession NZ_CP086769
Organism Pseudosulfitobacter pseudonitzschiae strain TT37-74

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE41_RS21855 Protein ID WP_224557924.1
Coordinates 80944..81366 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE41_RS21860 Protein ID WP_229939240.1
Coordinates 81370..81618 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE41_RS21845 (LOE41_21840) 77142..78200 - 1059 WP_224557922.1 HEPN domain-containing protein -
LOE41_RS21850 (LOE41_21845) 78197..80947 - 2751 WP_224557923.1 lactate dehydrogenase -
LOE41_RS21855 (LOE41_21850) 80944..81366 - 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE41_RS21860 (LOE41_21855) 81370..81618 - 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE41_RS21865 (LOE41_21860) 81766..82755 - 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE41_RS21870 (LOE41_21865) 82866..84323 - 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE41_RS21875 (LOE41_21870) 84326..85057 - 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE41_RS21880 (LOE41_21875) 85061..85705 - 645 WP_224557929.1 type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..95795 95795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224453 WP_224557924.1 NZ_CP086769:c81366-80944 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224453 NZ_CP120331:311878-312246 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224453 WP_229939240.1 NZ_CP086769:c81618-81370 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224453 NZ_CP120331:311660-311881 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References