Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3391938..3392518 Replicon chromosome
Accession NZ_CP086764
Organism Pseudosulfitobacter pseudonitzschiae strain TT37-74

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE41_RS16870 Protein ID WP_224556587.1
Coordinates 3391938..3392192 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE41_RS16875 Protein ID WP_224556600.1
Coordinates 3392189..3392518 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE41_RS16835 (LOE41_16840) 3388907..3389284 + 378 WP_229940765.1 hypothetical protein -
LOE41_RS16840 (LOE41_16845) 3389362..3389877 - 516 WP_224556573.1 hypothetical protein -
LOE41_RS16845 (LOE41_16850) 3389855..3390682 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE41_RS16850 (LOE41_16855) 3390679..3390840 - 162 WP_224556578.1 hypothetical protein -
LOE41_RS16855 (LOE41_16860) 3390840..3391292 - 453 WP_224556581.1 hypothetical protein -
LOE41_RS16860 (LOE41_16865) 3391368..3391538 - 171 WP_224556583.1 hypothetical protein -
LOE41_RS16865 (LOE41_16870) 3391638..3391826 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE41_RS16870 (LOE41_16875) 3391938..3392192 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE41_RS16875 (LOE41_16880) 3392189..3392518 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE41_RS16880 (LOE41_16885) 3392579..3392842 + 264 WP_224556602.1 hypothetical protein -
LOE41_RS16885 (LOE41_16890) 3392944..3393234 - 291 WP_224556604.1 hypothetical protein -
LOE41_RS16890 (LOE41_16895) 3393297..3393821 - 525 WP_224556606.1 hypothetical protein -
LOE41_RS16895 (LOE41_16900) 3394041..3394964 - 924 WP_229940510.1 phage minor head protein -
LOE41_RS16900 (LOE41_16905) 3395086..3395250 - 165 WP_229940508.1 hypothetical protein -
LOE41_RS16905 (LOE41_16910) 3395247..3395663 - 417 WP_229940505.1 hypothetical protein -
LOE41_RS16910 (LOE41_16915) 3395660..3395965 - 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE41_RS16915 (LOE41_16920) 3395962..3396216 - 255 WP_224556623.1 hypothetical protein -
LOE41_RS16920 (LOE41_16925) 3396213..3396371 - 159 WP_224556625.1 hypothetical protein -
LOE41_RS16925 (LOE41_16930) 3396368..3396556 - 189 WP_224556628.1 hypothetical protein -
LOE41_RS16930 (LOE41_16935) 3396556..3397446 - 891 WP_229940766.1 RNA ligase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3375168..3411759 36591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224451 WP_224556587.1 NZ_CP086764:3391938-3392192 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224451 NZ_CP120329:4489967-4490278 [Salmonella enterica subsp. enterica serovar Muenchen]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATGGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224451 WP_224556600.1 NZ_CP086764:3392189-3392518 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224451 NZ_CP120329:4490275-4490721 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAATCACTCAAC
CAACACCTGGAGAAAACACCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References