Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4629942..4630458 Replicon chromosome
Accession NZ_CP086761
Organism Klebsiella pneumoniae strain AZS099

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LON84_RS22590 Protein ID WP_002886902.1
Coordinates 4629942..4630226 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LON84_RS22595 Protein ID WP_002886901.1
Coordinates 4630216..4630458 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LON84_RS22565 (4625358) 4625358..4625621 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LON84_RS22570 (4625751) 4625751..4625924 + 174 WP_032410138.1 hypothetical protein -
LON84_RS22575 (4625927) 4625927..4626670 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
LON84_RS22580 (4627027) 4627027..4629165 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LON84_RS22585 (4629474) 4629474..4629938 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LON84_RS22590 (4629942) 4629942..4630226 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LON84_RS22595 (4630216) 4630216..4630458 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LON84_RS22600 (4630536) 4630536..4632446 - 1911 WP_009486549.1 PRD domain-containing protein -
LON84_RS22605 (4632469) 4632469..4633623 - 1155 WP_023302389.1 lactonase family protein -
LON84_RS22610 (4633690) 4633690..4634430 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T224444 WP_002886902.1 NZ_CP086761:c4630226-4629942 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T224444 NZ_CP120329:836073-836471 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTTGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT224444 WP_002886901.1 NZ_CP086761:c4630458-4630216 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT224444 NZ_CP120329:835846-836073 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References