Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 786265..786922 Replicon chromosome
Accession NZ_CP086761
Organism Klebsiella pneumoniae strain AZS099

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LON84_RS03925 Protein ID WP_002916310.1
Coordinates 786512..786922 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LON84_RS03920 Protein ID WP_002916312.1
Coordinates 786265..786531 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LON84_RS03895 (781421) 781421..782854 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LON84_RS03900 (782973) 782973..783701 - 729 WP_023342613.1 MurR/RpiR family transcriptional regulator -
LON84_RS03905 (783751) 783751..784062 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LON84_RS03910 (784226) 784226..784885 + 660 WP_002916317.1 hemolysin III family protein -
LON84_RS03915 (785036) 785036..786019 - 984 WP_023342614.1 tRNA-modifying protein YgfZ -
LON84_RS03920 (786265) 786265..786531 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LON84_RS03925 (786512) 786512..786922 + 411 WP_002916310.1 protein YgfX Toxin
LON84_RS03930 (786929) 786929..787450 - 522 WP_002916308.1 flavodoxin FldB -
LON84_RS03935 (787551) 787551..788447 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LON84_RS03940 (788470) 788470..789183 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LON84_RS03945 (789189) 789189..790922 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T224431 WP_002916310.1 NZ_CP086761:786512-786922 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T224431 NZ_CP120327:1105756-1106040 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT224431 WP_002916312.1 NZ_CP086761:786265-786531 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT224431 NZ_CP120327:1105524-1105766 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References