Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapD-relB/-
Location 1107799..1108456 Replicon chromosome
Accession NZ_CP086760
Organism Helicobacter pylori strain 3192

Toxin (Protein)


Gene name VapD Uniprot ID -
Locus tag LJN47_RS05225 Protein ID WP_220947903.1
Coordinates 1107799..1108083 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LJN47_RS05230 Protein ID WP_229929498.1
Coordinates 1108064..1108456 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN47_RS05205 (1104355) 1104355..1105122 - 768 WP_000242356.1 ABC transporter ATP-binding protein -
LJN47_RS05210 (1105122) 1105122..1106102 - 981 WP_000921449.1 iron ABC transporter permease -
LJN47_RS05215 (1106095) 1106095..1106937 - 843 WP_229929497.1 SDR family oxidoreductase -
LJN47_RS05220 (1107077) 1107077..1107601 + 525 WP_001135603.1 acyl-CoA thioesterase -
LJN47_RS05225 (1107799) 1107799..1108083 - 285 WP_220947903.1 endoribonuclease VapD Toxin
LJN47_RS05230 (1108064) 1108064..1108456 - 393 WP_229929498.1 hypothetical protein Antitoxin
LJN47_RS05235 (1108988) 1108988..1111213 - 2226 Protein_1032 Hop family adhesin BabA -
LJN47_RS05250 (1111710) 1111710..1112231 + 522 WP_229929499.1 hypothetical protein -
LJN47_RS05255 (1112182) 1112182..1113294 - 1113 WP_229929500.1 hydrogenase formation protein HypD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11162.71 Da        Isoelectric Point: 5.1974

>T224428 WP_220947903.1 NZ_CP086760:c1108083-1107799 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNHSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Download         Length: 285 bp

>T224428 NZ_CP120327:c153643-153275 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15271.40 Da        Isoelectric Point: 7.7122

>AT224428 WP_229929498.1 NZ_CP086760:c1108456-1108064 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIEALNELLQKISQAFDDKRDCCL
GRKIPNLETQEAMREALNGVNLTQIDSLDDLTNELKRENGKGFENVCFSV

Download         Length: 393 bp

>AT224428 NZ_CP120327:c153861-153640 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References