Detailed information of TA system TA224426

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 820586..821239
• Replicon: chromosome
• Accession: NZ_CP086759
• Organism: Acinetobacter baumannii strain ACI713

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LN920_RS03905
• Protein ID: WP_000607077.1
• Coordinates: 820586..820975 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: LN920_RS03910
• Protein ID: WP_001288210.1
• Coordinates: 820982..821239 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LN920_RS03890 (LN920_03890)	815704..817899	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
LN920_RS03895 (LN920_03895)	818087..818653	-	567	WP_000651538.1	rhombosortase	-
LN920_RS03900 (LN920_03900)	818731..819816	-	1086	WP_000049106.1	hypothetical protein	-
LN920_RS03905 (LN920_03905)	820586..820975	-	390	WP_000607077.1	membrane protein	Toxin
LN920_RS03910 (LN920_03910)	820982..821239	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
LN920_RS03915 (LN920_03915)	821427..822599	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
LN920_RS03920 (LN920_03920)	822648..824138	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
LN920_RS03925 (LN920_03925)	824320..824697	-	378	WP_001216380.1	50S ribosomal protein L17	-
LN920_RS03930 (LN920_03930)	824716..825723	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T224426 WP_000607077.1 NZ_CP086759:c820975-820586 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T224426 NZ_CP120326:c49048-48632 [Salmonella enterica subsp. enterica serovar Muenchen]
GTGAAGAAAATGTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCCGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGTATTGTGGTCTCGGCCATCACCTACTCAGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGTCACATTGAACTGGTTGACGCGTTCTGCGCCCGCCTCGATGCTATCCTGCCCTGGGACCGGGCC
GCGGTGAACGCCACCACGGAGATTAAGGTGGCGCTACGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATCGC
CGGGCACGCTATTGCCGCCGGCGCGGTACTGGTGACAAATAATACGCGGGAGTTTGAGCGGGTGCCGGGTCTTGTTCTGG
AAGACTGGGGAAGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT224426 WP_001288210.1 NZ_CP086759:c821239-820982 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT224426 NZ_CP120326:c49275-49045 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGATGGAGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGGCTTTATGGCGGAGCGTGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7