Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 727885..728564 | Replicon | chromosome |
| Accession | NZ_CP086759 | ||
| Organism | Acinetobacter baumannii strain ACI713 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | S3TWT7 |
| Locus tag | LN920_RS03345 | Protein ID | WP_000838146.1 |
| Coordinates | 728382..728564 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | N9L2H6 |
| Locus tag | LN920_RS03340 | Protein ID | WP_000966688.1 |
| Coordinates | 727885..728289 (-) | Length | 135 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LN920_RS03305 (LN920_03305) | 723178..723693 | - | 516 | WP_001056868.1 | Rha family transcriptional regulator | - |
| LN920_RS03310 (LN920_03310) | 724034..724969 | - | 936 | WP_000254125.1 | ORF6N domain-containing protein | - |
| LN920_RS03315 (LN920_03315) | 725119..725385 | + | 267 | WP_000774879.1 | hypothetical protein | - |
| LN920_RS03320 (LN920_03320) | 725428..725919 | - | 492 | WP_000755583.1 | DUF4468 domain-containing protein | - |
| LN920_RS03325 (LN920_03325) | 726005..726751 | - | 747 | WP_000599537.1 | hypothetical protein | - |
| LN920_RS03330 (LN920_03330) | 726813..727196 | - | 384 | WP_000725052.1 | hypothetical protein | - |
| LN920_RS03335 (LN920_03335) | 727261..727785 | - | 525 | WP_000721574.1 | DUF4468 domain-containing protein | - |
| LN920_RS03340 (LN920_03340) | 727885..728289 | - | 405 | WP_000966688.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LN920_RS03345 (LN920_03345) | 728382..728564 | - | 183 | WP_000838146.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LN920_RS03350 (LN920_03350) | 728891..729406 | - | 516 | WP_024616020.1 | hypothetical protein | - |
| LN920_RS03355 (LN920_03355) | 729477..730394 | - | 918 | WP_000094253.1 | phage tail tube protein | - |
| LN920_RS03360 (LN920_03360) | 730447..731802 | - | 1356 | WP_000002415.1 | hypothetical protein | - |
| LN920_RS03365 (LN920_03365) | 731802..732155 | - | 354 | WP_000064593.1 | hypothetical protein | - |
| LN920_RS03370 (LN920_03370) | 732252..732773 | - | 522 | WP_000749909.1 | SH3 domain-containing protein | - |
| LN920_RS03375 (LN920_03375) | 732882..733100 | - | 219 | WP_001277696.1 | hypothetical protein | - |
| LN920_RS03380 (LN920_03380) | 733102..733545 | - | 444 | WP_002016455.1 | phage tail terminator-like protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 707525..764757 | 57232 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6695.84 Da Isoelectric Point: 10.5523
>T224425 WP_000838146.1 NZ_CP086759:c728564-728382 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
Download Length: 183 bp
>T224425 NZ_CP120326:28888-29370 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGAAATAAGTGTTACTGCACCGGAGTTGCTAAACGAGGAACACTATCTTCAACAGTTTGATTGCGGGAATGATGTGCT
CAGTGACTGGCTTCGCCGCAGAGCGATGAAGAACCAATACCTCAATGCCTCCCGTACATTTGTTATCTGCCCTGAAGGCA
CAAAGCGAGTAGTGGGATATTACTCTATTGCGACGGGGTCTGTAAGTCATGCCAGTTTAGGTCGCAGTTTACGCCAGAAT
ATGCCCGATCCTGTTCCGGTTGTTTTGCTGGGACGTCTTGCTGTTGATGAGTGTACTCAAGGGCATAGTTTTGGAAAATG
GCTGCTTAATGATGCTGTAACACGGGTATCTAACCTGGCAGACCAGGTGGGTATTAAAGCGATCATGGTTCATGCTATTG
ATGAACAGGCGAAAACATTCTATGAATACTTTGGCTTTGTTCAGTCTCCCATTGCGCCAAATACATTGTTCTACAAGATT
TAA
ATGGAAATAAGTGTTACTGCACCGGAGTTGCTAAACGAGGAACACTATCTTCAACAGTTTGATTGCGGGAATGATGTGCT
CAGTGACTGGCTTCGCCGCAGAGCGATGAAGAACCAATACCTCAATGCCTCCCGTACATTTGTTATCTGCCCTGAAGGCA
CAAAGCGAGTAGTGGGATATTACTCTATTGCGACGGGGTCTGTAAGTCATGCCAGTTTAGGTCGCAGTTTACGCCAGAAT
ATGCCCGATCCTGTTCCGGTTGTTTTGCTGGGACGTCTTGCTGTTGATGAGTGTACTCAAGGGCATAGTTTTGGAAAATG
GCTGCTTAATGATGCTGTAACACGGGTATCTAACCTGGCAGACCAGGTGGGTATTAAAGCGATCATGGTTCATGCTATTG
ATGAACAGGCGAAAACATTCTATGAATACTTTGGCTTTGTTCAGTCTCCCATTGCGCCAAATACATTGTTCTACAAGATT
TAA
Antitoxin
Download Length: 135 a.a. Molecular weight: 14647.69 Da Isoelectric Point: 4.4328
>AT224425 WP_000966688.1 NZ_CP086759:c728289-727885 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
Download Length: 405 bp
>AT224425 NZ_CP120326:28613-28897 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCAAACTACAATCCGCAAATCTGTGCGTAATAAACAAATAAATATACGGGCTACTGATGAGGAACGTGCTGTGATTGA
TTATGCAGCGAGCCTGGTCAGTAAAAACCGTACCGACTTCATCATAGAAAAGGCTGTGAGCGAGGCCCAGAATATCATTC
TGGATCAACGCGTTTTTGTTCTGGATGATGCCCGCTATCAGGCTTTTATTAAACAACTTGAAGCTCCTGTACAGAATACT
GAAGGTCGTCAGCGCCTGATGGATGTGAAACCTGAATGGAAATAA
ATGCAAACTACAATCCGCAAATCTGTGCGTAATAAACAAATAAATATACGGGCTACTGATGAGGAACGTGCTGTGATTGA
TTATGCAGCGAGCCTGGTCAGTAAAAACCGTACCGACTTCATCATAGAAAAGGCTGTGAGCGAGGCCCAGAATATCATTC
TGGATCAACGCGTTTTTGTTCTGGATGATGCCCGCTATCAGGCTTTTATTAAACAACTTGAAGCTCCTGTACAGAATACT
GAAGGTCGTCAGCGCCTGATGGATGTGAAACCTGAATGGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|