Detailed information of TA system TA224424

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1385497..1386166
• Replicon: chromosome
• Accession: NZ_CP086728
• Organism: Streptococcus parasuis strain SS20

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: G7SGM1
• Locus tag: LOD77_RS07050
• Protein ID: WP_014637653.1
• Coordinates: 1385984..1386166 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LOD77_RS07045
• Protein ID: WP_160863757.1
• Coordinates: 1385497..1385946 (-)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOD77_RS07030 (LOD77_07020)	1380628..1383090	-	2463	WP_274505208.1	heavy metal translocating P-type ATPase	-
LOD77_RS07035 (LOD77_07025)	1383185..1384042	-	858	WP_274505209.1	SAM-dependent methyltransferase TehB	-
LOD77_RS07040 (LOD77_07030)	1384295..1385338	+	1044	WP_274505211.1	alcohol dehydrogenase catalytic domain-containing protein	-
LOD77_RS07045 (LOD77_07035)	1385497..1385946	-	450	WP_160863757.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LOD77_RS07050 (LOD77_07040)	1385984..1386166	-	183	WP_014637653.1	type II toxin-antitoxin system HicA family toxin	Toxin
LOD77_RS07055 (LOD77_07045)	1386544..1387011	-	468	WP_274505213.1	SsrA-binding protein SmpB	-
LOD77_RS07060 (LOD77_07050)	1387014..1389383	-	2370	WP_274505214.1	ribonuclease R	-
LOD77_RS07065 (LOD77_07055)	1389647..1389880	-	234	WP_171989834.1	preprotein translocase subunit SecG	-
LOD77_RS07070 (LOD77_07060)	1389927..1390076	-	150	WP_012775228.1	50S ribosomal protein L33	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-113)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6653.87 Da
• Isoelectric Point: 10.8207

>T224424 WP_014637653.1 NZ_CP086728:c1386166-1385984 [Streptococcus parasuis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Nucleotide

• Length: 183 bp

>T224424 NZ_CP120326:14791-15123 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTACTTAT
CGTTTCTCCGGCATCATTTAATAAGTTCACCCGGTTACCCGTTGTCGTTCCCGTCACCAGCGGCGGAGACTTTGCCCGCA
CAGCCGGTTTTACCGTCTCCCTGGACGGCGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAGCCCAGAACGATT
GATATGGGTGCCCGGAATGGTAAGCGTCTGGAACGTATACCCGAAGCTGTCGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16639.64 Da
• Isoelectric Point: 3.9790

>AT224424 WP_160863757.1 NZ_CP086728:c1385946-1385497 [Streptococcus parasuis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RDEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Nucleotide

• Length: 450 bp

>AT224424 NZ_CP120326:14533-14790 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGCTCT
GTCGACAGACAGCGAAGTGGGAATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCACAGTGCGATCCGCACGCCGAAATGAGCGATGAGGATAGGGAATGGATGGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA

Structures

Toxin

• AlphaFold DB: G7SGM1