Detailed information of TA system TA224423

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1343247..1343733
• Replicon: chromosome
• Accession: NZ_CP086728
• Organism: Streptococcus parasuis strain SS20

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOD77_RS06855
• Protein ID: WP_274505176.1
• Coordinates: 1343247..1343516 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LOD77_RS06860
• Protein ID: WP_130554954.1
• Coordinates: 1343506..1343733 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOD77_RS06825 (LOD77_06815)	1338359..1339333	-	975	WP_274505172.1	YvcK family protein	-
LOD77_RS06830 (LOD77_06820)	1339330..1340217	-	888	WP_274505173.1	RNase adapter RapZ	-
LOD77_RS06835 (LOD77_06825)	1340240..1340620	-	381	WP_274505174.1	RidA family protein	-
LOD77_RS06840 (LOD77_06830)	1340670..1341989	-	1320	WP_274505175.1	MATE family efflux transporter	-
LOD77_RS06845 (LOD77_06835)	1342468..1342806	-	339	WP_171989763.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LOD77_RS06850 (LOD77_06840)	1342806..1343093	-	288	WP_130554939.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
LOD77_RS06855 (LOD77_06845)	1343247..1343516	-	270	WP_274505176.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOD77_RS06860 (LOD77_06850)	1343506..1343733	-	228	WP_130554954.1	DUF6290 family protein	Antitoxin
LOD77_RS06865 (LOD77_06855)	1344071..1345417	-	1347	WP_274505178.1	asparagine--tRNA ligase	-
LOD77_RS06870 (LOD77_06860)	1345432..1346613	-	1182	WP_274505179.1	pyridoxal phosphate-dependent aminotransferase	-
LOD77_RS06875 (LOD77_06865)	1346610..1347107	-	498	WP_274505180.1	DUF5590 domain-containing protein	-
LOD77_RS06880 (LOD77_06870)	1347254..1347694	+	441	WP_171989767.1	MarR family transcriptional regulator	-
LOD77_RS06885 (LOD77_06875)	1347770..1348282	+	513	WP_274505182.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10483.54 Da
• Isoelectric Point: 10.4241

>T224423 WP_274505176.1 NZ_CP086728:c1343516-1343247 [Streptococcus parasuis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRIICDIIDNKMVILALEM
GHRKDIYRK

Nucleotide

• Length: 270 bp

>T224423 NZ_CP120325:4667742-4668053 [Salmonella enterica subsp. enterica serovar Muenchen]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8522.62 Da
• Isoelectric Point: 4.1707

>AT224423 WP_130554954.1 NZ_CP086728:c1343733-1343506 [Streptococcus parasuis]
MGIVSLRLNETEEEIFRSYAIHTGKSLSELFKSALIEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Nucleotide

• Length: 228 bp

>AT224423 NZ_CP120325:4668050-4668496 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAATCACTCAAC
CAACACCTGGAGAAAACACCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG