Detailed information of TA system TA224422

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1342468..1343093
• Replicon: chromosome
• Accession: NZ_CP086728
• Organism: Streptococcus parasuis strain SS20

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LOD77_RS06845
• Protein ID: WP_171989763.1
• Coordinates: 1342468..1342806 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: LOD77_RS06850
• Protein ID: WP_130554939.1
• Coordinates: 1342806..1343093 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOD77_RS06825 (LOD77_06815)	1338359..1339333	-	975	WP_274505172.1	YvcK family protein	-
LOD77_RS06830 (LOD77_06820)	1339330..1340217	-	888	WP_274505173.1	RNase adapter RapZ	-
LOD77_RS06835 (LOD77_06825)	1340240..1340620	-	381	WP_274505174.1	RidA family protein	-
LOD77_RS06840 (LOD77_06830)	1340670..1341989	-	1320	WP_274505175.1	MATE family efflux transporter	-
LOD77_RS06845 (LOD77_06835)	1342468..1342806	-	339	WP_171989763.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOD77_RS06850 (LOD77_06840)	1342806..1343093	-	288	WP_130554939.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LOD77_RS06855 (LOD77_06845)	1343247..1343516	-	270	WP_274505176.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LOD77_RS06860 (LOD77_06850)	1343506..1343733	-	228	WP_130554954.1	DUF6290 family protein	-
LOD77_RS06865 (LOD77_06855)	1344071..1345417	-	1347	WP_274505178.1	asparagine--tRNA ligase	-
LOD77_RS06870 (LOD77_06860)	1345432..1346613	-	1182	WP_274505179.1	pyridoxal phosphate-dependent aminotransferase	-
LOD77_RS06875 (LOD77_06865)	1346610..1347107	-	498	WP_274505180.1	DUF5590 domain-containing protein	-
LOD77_RS06880 (LOD77_06870)	1347254..1347694	+	441	WP_171989767.1	MarR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-106)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (10-81)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12914.84 Da
• Isoelectric Point: 5.9262

>T224422 WP_171989763.1 NZ_CP086728:c1342806-1342468 [Streptococcus parasuis]
MEKYRVIISPKLIEQIKSIRDYVANVKLSPETAERLVTAIFDEIESLELFPERGFDADEKIGVKIDKNGRSSRGITIQNG
KYIVIYTVNQEEHLVEVAFLFSSKTDYAKLFR

Nucleotide

• Length: 339 bp

>T224422 NZ_CP120325:c4666509-4666198 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10811.34 Da
• Isoelectric Point: 4.7494

>AT224422 WP_130554939.1 NZ_CP086728:c1343093-1342806 [Streptococcus parasuis]
MPTVIRDKQINFKVNSEYFELAKVVFQENGLDITSAFNEFVQEVAISKTLPFKTVEEKEREKLIARLQEEVSTSYEALKA
DKGLSVEEARKAVLG

Nucleotide

• Length: 288 bp

>AT224422 NZ_CP120325:c4666197-4665907 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA