Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 993644..994136 Replicon chromosome
Accession NZ_CP086728
Organism Streptococcus parasuis strain SS20

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LOD77_RS05085 Protein ID WP_172034832.1
Coordinates 993644..993901 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LOD77_RS05090 Protein ID WP_171988478.1
Coordinates 993885..994136 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOD77_RS05065 (LOD77_05055) 988962..990032 + 1071 WP_274505936.1 tyrosine recombinase XerS -
LOD77_RS05070 (LOD77_05060) 990310..991818 - 1509 WP_274504992.1 phosphomannomutase/phosphoglucomutase -
LOD77_RS05075 (LOD77_05065) 991999..992940 - 942 WP_274504993.1 sensor histidine kinase -
LOD77_RS05080 (LOD77_05070) 992937..993605 - 669 WP_274504994.1 response regulator transcription factor -
LOD77_RS05085 (LOD77_05075) 993644..993901 - 258 WP_172034832.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOD77_RS05090 (LOD77_05080) 993885..994136 - 252 WP_171988478.1 DUF6290 family protein Antitoxin
LOD77_RS05095 (LOD77_05085) 994371..996341 - 1971 WP_274504995.1 ABC transporter permease -
LOD77_RS05100 (LOD77_05090) 996342..997094 - 753 WP_174845939.1 ABC transporter ATP-binding protein -
LOD77_RS05105 (LOD77_05095) 997103..997492 - 390 WP_274504996.1 NisI/SpaI family lantibiotic immunity lipoprotein -
LOD77_RS05110 (LOD77_05100) 997505..997645 - 141 WP_172036121.1 hypothetical protein -
LOD77_RS05115 (LOD77_05105) 997784..998950 - 1167 WP_274504997.1 carbamoyl phosphate synthase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9928.52 Da        Isoelectric Point: 10.8924

>T224421 WP_172034832.1 NZ_CP086728:c993901-993644 [Streptococcus parasuis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKVTVTSLKM
RNGSI

Download         Length: 258 bp

>T224421 NZ_CP120325:c4216821-4216537 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9351.58 Da        Isoelectric Point: 3.7128

>AT224421 WP_171988478.1 NZ_CP086728:c994136-993885 [Streptococcus parasuis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALAEYQEDLANGIEPISWEEMLEELGLTNE
DLL

Download         Length: 252 bp

>AT224421 NZ_CP120325:c4217053-4216811 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References