Detailed information of TA system TA224419

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 160212..160606
• Replicon: chromosome
• Accession: NZ_CP086728
• Organism: Streptococcus parasuis strain SS20

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LOD77_RS00850
• Protein ID: WP_239604456.1
• Coordinates: 160436..160606 (+)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: LOD77_RS00845
• Protein ID: WP_274505528.1
• Coordinates: 160212..160340 (+)
• Length: 43 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOD77_RS00810 (LOD77_00800)	155269..155628	+	360	WP_174846592.1	ribonuclease P protein component	-
LOD77_RS00815 (LOD77_00805)	155612..156424	+	813	WP_274505527.1	YidC/Oxa1 family membrane protein insertase	-
LOD77_RS00820 (LOD77_00810)	156443..157447	+	1005	WP_171988964.1	RNA-binding cell elongation regulator Jag/EloR	-
LOD77_RS00825 (LOD77_00815)	157669..157806	+	138	WP_049618373.1	50S ribosomal protein L34	-
LOD77_RS00830 (LOD77_00820)	157856..158737	-	882	WP_174846590.1	diacylglycerol kinase family lipid kinase	-
LOD77_RS00835 (LOD77_00825)	158887..159669	+	783	WP_171988962.1	TatD family hydrolase	-
LOD77_RS00840 (LOD77_00830)	159653..160219	+	567	WP_171989046.1	ribonuclease M5	-
LOD77_RS00845	160212..160340	+	129	WP_274505528.1	hypothetical protein	Antitoxin
LOD77_RS00850 (LOD77_00835)	160436..160606	+	171	WP_239604456.1	hypothetical protein	Toxin
LOD77_RS00855 (LOD77_00840)	160613..160865	+	253	Protein_147	NUDIX domain-containing protein	-
LOD77_RS00860 (LOD77_00845)	160904..161776	+	873	WP_274505529.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
LOD77_RS00865 (LOD77_00850)	163015..163761	+	747	WP_274505530.1	amino acid transporter	-
LOD77_RS00870 (LOD77_00855)	163771..164349	+	579	WP_239604458.1	CPBP family intramembrane metalloprotease	-
LOD77_RS00875 (LOD77_00860)	164361..164789	+	429	WP_171988959.1	Msa family membrane protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	159653..170552	10899

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6555.70 Da
• Isoelectric Point: 10.3173

>T224419 WP_239604456.1 NZ_CP086728:160436-160606 [Streptococcus parasuis]
MSFNADNRFGKQIDPLHLTRGYVIGKDYIALYRVVKNELRVVHLFATKSDYVKLLK

Nucleotide

• Length: 171 bp

>T224419 NZ_CP120325:3723638-3723913 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGAATGCCTCCGGCGTTAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Protein

• Length: 43 a.a.
• Molecular weight: 4754.44 Da
• Isoelectric Point: 3.6534

>AT224419 WP_274505528.1 NZ_CP086728:160212-160340 [Streptococcus parasuis]
MSELETGKEVFAMNELDLTASFNLILQNIAVKNELLILTEEE

Nucleotide

• Length: 129 bp

>AT224419 NZ_CP120325:c3723903-3723481 [Salmonella enterica subsp. enterica serovar Muenchen]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTAACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT