224416

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2719257..2719950 Replicon chromosome
Accession NZ_CP086726
Organism Enterococcus faecalis strain E533

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag LM507_RS13135 Protein ID WP_002395798.1
Coordinates 2719257..2719601 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag LM507_RS13140 Protein ID WP_002364355.1
Coordinates 2719618..2719950 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LM507_RS13105 (2714530) 2714530..2715498 + 969 WP_002364362.1 competence type IV pilus ATPase ComGA -
LM507_RS13110 (2715455) 2715455..2716501 + 1047 WP_002356990.1 competence type IV pilus assembly protein ComGB -
LM507_RS13115 (2716501) 2716501..2716776 + 276 WP_002356991.1 competence type IV pilus major pilin ComGC -
LM507_RS13120 (2716773) 2716773..2717216 + 444 WP_025189979.1 competence type IV pilus minor pilin ComGD -
LM507_RS13125 (2717244) 2717244..2718392 - 1149 WP_229022057.1 site-specific integrase -
LM507_RS13130 (2718489) 2718489..2719223 - 735 WP_010820096.1 potassium channel family protein -
LM507_RS13135 (2719257) 2719257..2719601 - 345 WP_002395798.1 ImmA/IrrE family metallo-endopeptidase Toxin
LM507_RS13140 (2719618) 2719618..2719950 - 333 WP_002364355.1 helix-turn-helix transcriptional regulator Antitoxin
LM507_RS13145 (2720262) 2720262..2720438 + 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
LM507_RS13150 (2720449) 2720449..2720760 + 312 WP_002381719.1 hypothetical protein -
LM507_RS13155 (2720767) 2720767..2720982 + 216 WP_010783773.1 hypothetical protein -
LM507_RS13160 (2721022) 2721022..2721345 + 324 WP_010820095.1 hypothetical protein -
LM507_RS13165 (2721342) 2721342..2721566 + 225 WP_002391454.1 hypothetical protein -
LM507_RS13170 (2721669) 2721669..2722685 + 1017 WP_010820093.1 RecT family recombinase -
LM507_RS13175 (2722648) 2722648..2723463 + 816 WP_010783770.1 PD-(D/E)XK nuclease-like domain-containing protein -
LM507_RS13180 (2723478) 2723478..2724215 + 738 WP_104670766.1 DnaD domain protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2716800..2758311 41511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-81)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13718.69 Da        Isoelectric Point: 6.1363

>T224416 WP_002395798.1 NZ_CP086726:c2719601-2719257 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLK

Download         Length: 345 bp

>T224416 NZ_CP120325:c1017839-1017312 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12691.16 Da        Isoelectric Point: 4.6307

>AT224416 WP_002364355.1 NZ_CP086726:c2719950-2719618 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp

>AT224416 NZ_CP120325:c1018126-1017836 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References