Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 1668646..1669217 Replicon chromosome
Accession NZ_CP086726
Organism Enterococcus faecalis strain E533

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LM507_RS08035 Protein ID WP_002354774.1
Coordinates 1668876..1669217 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag LM507_RS08030 Protein ID WP_002354773.1
Coordinates 1668646..1668876 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LM507_RS08010 (1664883) 1664883..1666178 + 1296 WP_010815865.1 ATP-binding protein -
LM507_RS08015 (1666187) 1666187..1666819 + 633 WP_002358972.1 RloB family protein -
LM507_RS08020 (1666886) 1666886..1667878 - 993 WP_002365428.1 biotin--[acetyl-CoA-carboxylase] ligase -
LM507_RS08025 (1668017) 1668017..1668232 + 216 WP_002354768.1 zinc ribbon domain-containing protein -
LM507_RS08030 (1668646) 1668646..1668876 + 231 WP_002354773.1 hypothetical protein Antitoxin
LM507_RS08035 (1668876) 1668876..1669217 + 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LM507_RS08040 (1669588) 1669588..1673202 + 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T224404 WP_002354774.1 NZ_CP086726:1668876-1669217 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

>T224404 NZ_CP120322:2025171-2025274 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT224404 WP_002354773.1 NZ_CP086726:1668646-1668876 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp

>AT224404 NZ_CP120322:c2025276-2025131 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References