Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 730742..731276 Replicon chromosome
Accession NZ_CP086726
Organism Enterococcus faecalis strain E533

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag LM507_RS03480 Protein ID WP_002360769.1
Coordinates 730742..731017 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag LM507_RS03485 Protein ID WP_002369771.1
Coordinates 731010..731276 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LM507_RS03450 (725790) 725790..726728 - 939 WP_002370935.1 2-dehydropantoate 2-reductase -
LM507_RS03455 (726856) 726856..727185 - 330 WP_002358661.1 LPXTG cell wall anchor domain-containing protein -
LM507_RS03460 (727215) 727215..727400 + 186 WP_002358660.1 hypothetical protein -
LM507_RS03465 (727432) 727432..728040 + 609 Protein_672 IS6 family transposase -
LM507_RS03470 (728709) 728709..729683 - 975 WP_002355428.1 choloylglycine hydrolase -
LM507_RS03475 (729907) 729907..730551 + 645 WP_002377952.1 IS6 family transposase -
LM507_RS03480 (730742) 730742..731017 - 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
LM507_RS03485 (731010) 731010..731276 - 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LM507_RS03490 (731387) 731387..731971 - 585 WP_002377949.1 thermonuclease family protein -
LM507_RS03495 (731995) 731995..732411 - 417 WP_010710134.1 single-stranded DNA-binding protein -
LM507_RS03500 (732487) 732487..732735 - 249 WP_002360773.1 DUF3850 domain-containing protein -
LM507_RS03505 (732748) 732748..733248 - 501 WP_002360775.1 DnaJ domain-containing protein -
LM507_RS03510 (733281) 733281..733547 - 267 WP_002377947.1 hypothetical protein -
LM507_RS03515 (734139) 734139..734627 - 489 WP_048945224.1 hypothetical protein -
LM507_RS03520 (734633) 734633..735418 - 786 WP_048945223.1 replication-relaxation family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T224393 WP_002360769.1 NZ_CP086726:c731017-730742 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

>T224393 NZ_CP120318:4530605-4530916 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT224393 WP_002369771.1 NZ_CP086726:c731276-731010 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp

>AT224393 NZ_CP120318:4530913-4531359 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References