Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4774600..4775116 Replicon chromosome
Accession NZ_CP086724
Organism Klebsiella pneumoniae strain KP_3

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LOQ45_RS23110 Protein ID WP_002886902.1
Coordinates 4774600..4774884 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LOQ45_RS23115 Protein ID WP_002886901.1
Coordinates 4774874..4775116 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOQ45_RS23085 (4770017) 4770017..4770280 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
LOQ45_RS23090 (4770410) 4770410..4770583 + 174 WP_032410138.1 hypothetical protein -
LOQ45_RS23095 (4770586) 4770586..4771329 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
LOQ45_RS23100 (4771686) 4771686..4773824 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LOQ45_RS23105 (4774132) 4774132..4774596 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LOQ45_RS23110 (4774600) 4774600..4774884 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOQ45_RS23115 (4774874) 4774874..4775116 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LOQ45_RS23120 (4775194) 4775194..4777104 - 1911 WP_117259253.1 PRD domain-containing protein -
LOQ45_RS23125 (4777127) 4777127..4778281 - 1155 WP_002886900.1 lactonase family protein -
LOQ45_RS23130 (4778348) 4778348..4779088 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T224388 WP_002886902.1 NZ_CP086724:c4774884-4774600 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T224388 NZ_CP120318:c4021907-4021620 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT224388 WP_002886901.1 NZ_CP086724:c4775116-4774874 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT224388 NZ_CP120318:c4021633-4021331 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References