Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4033757..4034376 Replicon chromosome
Accession NZ_CP086724
Organism Klebsiella pneumoniae strain KP_3

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LOQ45_RS19565 Protein ID WP_002892050.1
Coordinates 4034158..4034376 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LOQ45_RS19560 Protein ID WP_002892066.1
Coordinates 4033757..4034131 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOQ45_RS19550 (4028910) 4028910..4030103 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LOQ45_RS19555 (4030126) 4030126..4033272 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LOQ45_RS19560 (4033757) 4033757..4034131 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LOQ45_RS19565 (4034158) 4034158..4034376 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LOQ45_RS19570 (4034535) 4034535..4035101 + 567 WP_002892030.1 maltose O-acetyltransferase -
LOQ45_RS19575 (4035073) 4035073..4035213 - 141 WP_004147370.1 hypothetical protein -
LOQ45_RS19580 (4035234) 4035234..4035704 + 471 WP_002892026.1 YlaC family protein -
LOQ45_RS19585 (4035679) 4035679..4037130 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LOQ45_RS19590 (4037231) 4037231..4037929 + 699 WP_002892021.1 GNAT family protein -
LOQ45_RS19595 (4037926) 4037926..4038066 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LOQ45_RS19600 (4038066) 4038066..4038329 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T224385 WP_002892050.1 NZ_CP086724:4034158-4034376 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T224385 NZ_CP120318:c2727713-2727610 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT224385 WP_002892066.1 NZ_CP086724:4033757-4034131 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT224385 NZ_CP120318:2727608-2727753 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References