22438

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4483642..4484237 Replicon chromosome
Accession NC_009800
Organism Escherichia coli HS

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag ECHS_RS22055 Protein ID WP_000239579.1
Coordinates 4483887..4484237 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag ECHS_RS22050 Protein ID WP_001223208.1
Coordinates 4483642..4483893 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECHS_RS22040 (EcHS_A4475) 4479307..4483086 + 3780 WP_000060852.1 autotransporter assembly complex protein TamB -
ECHS_RS22045 (EcHS_A4476) 4483089..4483430 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
ECHS_RS22050 (EcHS_A4477) 4483642..4483893 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
ECHS_RS22055 (EcHS_A4478) 4483887..4484237 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
ECHS_RS22060 (EcHS_A4479) 4484317..4484847 - 531 WP_000055075.1 inorganic diphosphatase -
ECHS_RS22065 (EcHS_A4481) 4485157..4486113 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
ECHS_RS22070 (EcHS_A4482) 4486253..4487755 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
ECHS_RS22075 (EcHS_A4483) 4487769..4488791 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T22438 WP_000239579.1 NC_009800:4483887-4484237 [Escherichia coli HS]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T22438 NC_009800:4483887-4484237 [Escherichia coli HS]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT22438 WP_001223208.1 NC_009800:4483642-4483893 [Escherichia coli HS]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT22438 NC_009800:4483642-4483893 [Escherichia coli HS]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References