Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 1679936..1680980 Replicon chromosome
Accession NZ_CP086678
Organism Escherichia coli strain EFF60

Toxin (Protein)


Gene name panT Uniprot ID A0A839B4R0
Locus tag LMF34_RS08110 Protein ID WP_000019187.1
Coordinates 1679936..1680484 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag LMF34_RS08115 Protein ID WP_000287252.1
Coordinates 1680507..1680980 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMF34_RS08060 (1675019) 1675019..1675843 + 825 WP_000081287.1 DUF2303 family protein -
LMF34_RS08065 (1675971) 1675971..1676507 + 537 WP_000008200.1 5'-deoxynucleotidase -
LMF34_RS08070 (1676498) 1676498..1676623 + 126 Protein_1580 hypothetical protein -
LMF34_RS08075 (1677010) 1677010..1677495 + 486 WP_248422889.1 class I SAM-dependent methyltransferase -
LMF34_RS08080 (1677492) 1677492..1678091 + 600 WP_248422890.1 ead/Ea22-like family protein -
LMF34_RS08085 (1678093) 1678093..1678284 + 192 WP_001014294.1 hypothetical protein -
LMF34_RS08090 (1678287) 1678287..1678583 + 297 Protein_1584 DUF551 domain-containing protein -
LMF34_RS08095 (1678830) 1678830..1679021 + 192 WP_248422892.1 DUF551 domain-containing protein -
LMF34_RS08100 (1679021) 1679021..1679593 + 573 WP_001061350.1 3'-5' exonuclease -
LMF34_RS08105 (1679630) 1679630..1679902 + 273 WP_001093913.1 pyocin activator PrtN family protein -
LMF34_RS08110 (1679936) 1679936..1680484 - 549 WP_000019187.1 hypothetical protein Toxin
LMF34_RS08115 (1680507) 1680507..1680980 - 474 WP_000287252.1 DUF4065 domain-containing protein Antitoxin
LMF34_RS08120 (1681285) 1681285..1681389 - 105 Protein_1590 tRNA-dihydrouridine synthase -
LMF34_RS08125 (1681752) 1681752..1682708 - 957 WP_000014226.1 DUF2713 family protein -
LMF34_RS08130 (1683026) 1683026..1683541 + 516 WP_000416263.1 zinc uptake transcriptional repressor Zur -
LMF34_RS08135 (1683583) 1683583..1683792 - 210 WP_001030593.1 CsbD family protein -
LMF34_RS08140 (1683908) 1683908..1685233 - 1326 WP_021523322.1 MATE family efflux transporter DinF -
LMF34_RS08145 (1685306) 1685306..1685914 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1642514..1685914 43400


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 19966.42 Da        Isoelectric Point: 4.5662

>T224349 WP_000019187.1 NZ_CP086678:c1680484-1679936 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQIFKSAFEPSNHESDDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

>T224349 NZ_CP120211:c523713-523399 [Agrobacterium leguminum]
ATGAACAGCTTCGAGAAATCGGCAGAGTTCGACGAATGGCTGAAGGCATTGAAAGATCGTGCCGGAAAGGTGCGGATTCT
TCATCGTCTCACCGCGGCCGAGCATGGGAATTTCGGCGATTGTGAGCCGGTGGGTGGAGGCGTTTCAGAAATGCGTATCC
ACTACGGCCCGGGTTATCGGGTCTATTTCACCCGCGTTGGCAAGAGGATTTACTTCCTTCTGATCGGCGGGGACAAGTCT
TCGCAAAAGCGGGACATAAAACGCGCAATCGGGATGGCGCAGACAATAGGAAGGGATGGCCGTGACGGAATTTAG

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT224349 WP_000287252.1 NZ_CP086678:c1680980-1680507 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT224349 NZ_CP120211:c523418-523119 [Agrobacterium leguminum]
ATGGCCGTGACGGAATTTAGCCAATTCGATGTGTCGGACTATCTGGATAGCGATGAAGCCATGATCGAATATCTGGCGGT
TGCGATGGAAGATGAAAACCCTGACGTGTTCATTGCCGCCCTTGGCGCCGTCGCCAGAGCTCGCGGAATGTCACATGTTG
CTGATGCTTCGGGTCTGGGTCGCGAAAGCCTCTACAAAGCACTTAAGCCCGGTTCGAAGCTTCGCTATGAAACCGTGCAG
AAAGTCCTGCATGCGCTGGGCTTCCGACTGGCCGTCGAAAAATCATTGAGCGCCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839B4R0

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References