Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1446752..1447274 Replicon chromosome
Accession NZ_CP086678
Organism Escherichia coli strain EFF60

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag LMF34_RS06900 Protein ID WP_001105433.1
Coordinates 1446752..1447042 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag LMF34_RS06905 Protein ID WP_000212715.1
Coordinates 1447032..1447274 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMF34_RS06885 (1441915) 1441915..1443570 + 1656 WP_021523332.1 alpha,alpha-phosphotrehalase -
LMF34_RS06890 (1443964) 1443964..1446102 + 2139 WP_248422886.1 anaerobic ribonucleoside-triphosphate reductase -
LMF34_RS06895 (1446287) 1446287..1446751 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LMF34_RS06900 (1446752) 1446752..1447042 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LMF34_RS06905 (1447032) 1447032..1447274 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LMF34_RS06910 (1447466) 1447466..1447852 - 387 WP_001232246.1 cytochrome b562 -
LMF34_RS06915 (1448036) 1448036..1449388 - 1353 WP_001162173.1 metalloprotease PmbA -
LMF34_RS06920 (1449482) 1449482..1450033 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
LMF34_RS06925 (1450185) 1450185..1451558 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T224346 WP_001105433.1 NZ_CP086678:c1447042-1446752 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T224346 NZ_CP120211:c354222-353965 [Agrobacterium leguminum]
GTGATCTGGACAATTGAATATCACGCGCTTGTCCAGAAAGAGATGCGCAAGATAAATCCGGAAACGCGCCAGCGAATCCG
GAGTTTTCTGCACGAACGATTGGCGGCACTGGATGATCCACGCCAGACCGGCACCGCCCTGCAAGACTCCGAGCGTGGAA
ATTTCTGGCGCTACCGGGTGGGCGATTACCGCATCATCTGCGATATACAGGATCACAAGCTCGTCGTGCTGGTGGTCGAA
ATCGGCCATCGCCGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT224346 WP_000212715.1 NZ_CP086678:c1447274-1447032 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT224346 NZ_CP120211:c354433-354206 [Agrobacterium leguminum]
ATGAGCAAACAGACGGCCATCCGCCTGCCTGATGAGACCTATGAGCGGCTGAAGGCGCTGTCCGAGCGCACCGGCCGCAC
ATCCGCCTATTACATCCGCGAGGCGATCGAGAAACATATCGAGGATATGGAAGATCTCCATCTCGCCGAGGAAGCGACGC
GGCGCATCCAGCGTGGAGAATCGAAGGTTGTAAGCGCCGAGGAGTTCTGGCGTGATCTGGACAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References