Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4955254..4956935 | Replicon | chromosome |
| Accession | NZ_CP086664 | ||
| Organism | Klebsiella pneumoniae strain SCPM-O-B-8912 (11PKP/19a) | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A483YLF8 |
| Locus tag | KFX87_RS24190 | Protein ID | WP_019724882.1 |
| Coordinates | 4955254..4956171 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A6TH05 |
| Locus tag | KFX87_RS24195 | Protein ID | WP_004177809.1 |
| Coordinates | 4956177..4956935 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFX87_RS24170 (KFX87_024165) | 4950560..4952080 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| KFX87_RS24175 (KFX87_024170) | 4952077..4953075 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| KFX87_RS24180 (KFX87_024175) | 4953106..4954047 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| KFX87_RS24185 (KFX87_024180) | 4954122..4955129 | + | 1008 | WP_015959270.1 | carbohydrate kinase family protein | - |
| KFX87_RS24190 (KFX87_024185) | 4955254..4956171 | - | 918 | WP_019724882.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| KFX87_RS24195 (KFX87_024190) | 4956177..4956935 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| KFX87_RS24200 (KFX87_024195) | 4957021..4957749 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
| KFX87_RS24205 (KFX87_024200) | 4958022..4960169 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| KFX87_RS24210 (KFX87_024205) | 4960399..4961085 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34653.14 Da Isoelectric Point: 5.4707
>T224334 WP_019724882.1 NZ_CP086664:c4956171-4955254 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T224334 NZ_CP119986:c3655579-3655166 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT224334 WP_004177809.1 NZ_CP086664:c4956935-4956177 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT224334 NZ_CP119986:c3655826-3655560 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A483YLF8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A6TH05 |