Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3578385..3578980 Replicon chromosome
Accession NZ_CP086662
Organism Escherichia coli strain E2

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag LOE88_RS17140 Protein ID WP_000239579.1
Coordinates 3578630..3578980 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag LOE88_RS17135 Protein ID WP_001223208.1
Coordinates 3578385..3578636 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE88_RS17125 (3574049) 3574049..3577828 + 3780 WP_000060921.1 autotransporter assembly complex protein TamB -
LOE88_RS17130 (3577831) 3577831..3578172 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LOE88_RS17135 (3578385) 3578385..3578636 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LOE88_RS17140 (3578630) 3578630..3578980 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
LOE88_RS17145 (3579060) 3579060..3579590 - 531 WP_000055070.1 inorganic diphosphatase -
LOE88_RS17150 (3579900) 3579900..3580856 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LOE88_RS17155 (3580996) 3580996..3582498 + 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
LOE88_RS17160 (3582512) 3582512..3583534 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T224312 WP_000239579.1 NZ_CP086662:3578630-3578980 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T224312 NZ_CP119984:c909278-909021 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT224312 WP_001223208.1 NZ_CP086662:3578385-3578636 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT224312 NZ_CP119984:909103-909435 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References