224309

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2726797..2727383 Replicon chromosome
Accession NZ_CP086662
Organism Escherichia coli strain E2

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag LOE88_RS13155 Protein ID WP_042014162.1
Coordinates 2727153..2727383 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag LOE88_RS13150 Protein ID WP_000593555.1
Coordinates 2726797..2727156 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE88_RS13125 (2722929) 2722929..2723873 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
LOE88_RS13130 (2723870) 2723870..2724703 + 834 WP_001008968.1 nickel ABC transporter permease subunit NikC -
LOE88_RS13135 (2724703) 2724703..2725467 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
LOE88_RS13140 (2725464) 2725464..2726270 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
LOE88_RS13145 (2726276) 2726276..2726677 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
LOE88_RS13150 (2726797) 2726797..2727156 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE88_RS13155 (2727153) 2727153..2727383 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE88_RS13160 (2727487) 2727487..2728611 - 1125 WP_001314210.1 ABC transporter permease -
LOE88_RS13165 (2728611) 2728611..2731346 - 2736 WP_000149168.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T224309 WP_042014162.1 NZ_CP086662:c2727383-2727153 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T224309 NZ_CP119983:c224063-223911 [Salmonella enterica]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT224309 WP_000593555.1 NZ_CP086662:c2727156-2726797 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT224309 NZ_CP119983:224115-224175 [Salmonella enterica]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References