Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2105816..2106291 Replicon chromosome
Accession NZ_CP086659
Organism Staphylococcus capitis strain XZ03

Toxin (Protein)


Gene name TsaT Uniprot ID A0A1J4E6X5
Locus tag LN243_RS10255 Protein ID WP_002433387.1
Coordinates 2106106..2106291 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A1J4E704
Locus tag LN243_RS10250 Protein ID WP_023350634.1
Coordinates 2105816..2106073 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN243_RS10215 2101070..2101789 - 720 WP_030064992.1 type I 3-dehydroquinate dehydratase -
LN243_RS10220 2101959..2102381 + 423 WP_002433175.1 organic hydroperoxide resistance protein -
LN243_RS10225 2102790..2103296 + 507 WP_030064990.1 GNAT family N-acetyltransferase -
LN243_RS10230 2103477..2104094 + 618 WP_030064988.1 LysE/ArgO family amino acid transporter -
LN243_RS10235 2104150..2104734 - 585 WP_030064986.1 histidine phosphatase family protein -
LN243_RS10240 2104946..2105182 + 237 WP_002433110.1 hypothetical protein -
LN243_RS10245 2105174..2105377 - 204 WP_002432976.1 sterile alpha motif-like domain-containing protein -
LN243_RS10250 2105816..2106073 + 258 WP_023350634.1 hypothetical protein Antitoxin
LN243_RS10255 2106106..2106291 + 186 WP_002433387.1 hypothetical protein Toxin
LN243_RS10260 2106485..2107069 + 585 WP_030064984.1 lipoprotein N-acylation protein LnsA -
LN243_RS10265 2107132..2107365 - 234 WP_002433190.1 hypothetical protein -
LN243_RS10270 2107499..2108104 - 606 WP_002433231.1 GNAT family N-acetyltransferase -
LN243_RS10275 2108285..2109031 + 747 WP_023350637.1 poly-gamma-glutamate hydrolase family protein -
LN243_RS10280 2109152..2109436 + 285 WP_030064982.1 hypothetical protein -
LN243_RS10285 2109460..2109684 + 225 WP_002433282.1 hypothetical protein -
LN243_RS10290 2109994..2110728 - 735 WP_030064980.1 SGNH/GDSL hydrolase family protein -
LN243_RS10295 2110851..2111051 - 201 WP_002433447.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7022.71 Da        Isoelectric Point: 9.7844

>T224292 WP_002433387.1 NZ_CP086659:2106106-2106291 [Staphylococcus capitis]
VSLHFQILLWLAIIFIVAGAIILTIMLKTKKEERKESYLGFTVIFLIFGFAMLIYTLIFGL

Download         Length: 186 bp

>T224292 NZ_CP119981:c224063-223911 [Salmonella enterica]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9786.89 Da        Isoelectric Point: 3.6988

>AT224292 WP_023350634.1 NZ_CP086659:2105816-2106073 [Staphylococcus capitis]
MKIFSINVINILLTILFIAFNVLITYNANVDNQLWLIPGLCICGVALFTSLIIAIIYTDLLSEIIFFINIVLALYYIYPI
FYDFL

Download         Length: 258 bp

>AT224292 NZ_CP119981:224115-224175 [Salmonella enterica]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4E6X5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E704

References