Detailed information of TA system TA224288

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1107741..1108547
• Replicon: chromosome
• Accession: NZ_CP086659
• Organism: Staphylococcus capitis strain XZ03

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: A0A507SPY8
• Locus tag: LN243_RS05545
• Protein ID: WP_023350045.1
• Coordinates: 1108368..1108547 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: LN243_RS05540
• Protein ID: WP_168992767.1
• Coordinates: 1107741..1108340 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LN243_RS05520	1103629..1105086	+	1458	WP_023350042.1	ABC transporter substrate-binding protein/permease	-
LN243_RS05525	1105079..1105801	+	723	WP_030063521.1	amino acid ABC transporter ATP-binding protein	-
LN243_RS05530	1105925..1107088	+	1164	WP_087671673.1	tRNA epoxyqueuosine(34) reductase QueG	-
LN243_RS05535	1107091..1107561	+	471	WP_023350044.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
LN243_RS05540	1107741..1108340	+	600	WP_168992767.1	glucosamine-6-phosphate isomerase	Antitoxin
LN243_RS05545	1108368..1108547	+	180	WP_023350045.1	SAS053 family protein	Toxin
LN243_RS05550	1108734..1109132	+	399	WP_023350046.1	hypothetical protein	-
LN243_RS05555	1109286..1110671	+	1386	WP_023350047.1	class II fumarate hydratase	-
LN243_RS05560	1110769..1111600	-	832	Protein_1063	RluA family pseudouridine synthase	-
LN243_RS05565	1111776..1112888	+	1113	WP_030063524.1	GAF domain-containing sensor histidine kinase	-
LN243_RS05570	1112908..1113531	+	624	WP_023350050.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 7012.37 Da
• Isoelectric Point: 3.8420

>T224288 WP_023350045.1 NZ_CP086659:1108368-1108547 [Staphylococcus capitis]
MNKEYESKLNYHEEENAMVTDLDDLKELGKEMEQISEENDEDKLNQSHDEDVHSDLNNE

Nucleotide

• Length: 180 bp

>T224288 NZ_CP119981:14789-15121 [Salmonella enterica]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTACTTAT
CGTTTCTCCGGCATCATTTAATAAGTTCACCCGGTTACCCGTTGTCGTTCCCGTCACCAGCGGCGGAGACTTTGCCCGCA
CAGCCGGTTTTACCGTCTCCCTGGACGGCGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAGCCCAGAACGATT
GATATGGGTGCCCGGAATGGTAAGCGTCTGGAACGTATACCCGAAGCTGTCGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22734.66 Da
• Isoelectric Point: 4.7928

>AT224288 WP_168992767.1 NZ_CP086659:1107741-1108340 [Staphylococcus capitis]
MAMNFKVFENSERVAEYAADIIRKQFNNNPTTIAGFHLEKDHAPVLDELKKNVDTHALDFSQINILDYDDNRSYYEALGV
PESQVYSISYEQDAIDFISDKMKTKENKGKLILQVLSIDESGKLDVSVRQGLMEAREIFLVVTGSNKREVIEKLYRENGK
SSYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARYV

Nucleotide

• Length: 600 bp

>AT224288 NZ_CP119981:14531-14788 [Salmonella enterica]
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGCTCT
GTCGACAGACAGCGAAGTGGGAATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCACAGTGCGATCCGCACGCCGAAATGAGCGATGAGGATAGGGAATGGATGGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA

Structures

Toxin

• AlphaFold DB: A0A507SPY8