Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 964613..965238 Replicon chromosome
Accession NZ_CP086659
Organism Staphylococcus capitis strain XZ03

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag LN243_RS04650 Protein ID WP_002504557.1
Coordinates 964843..965238 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag LN243_RS04645 Protein ID WP_002504558.1
Coordinates 964613..964843 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN243_RS04580 959682..960164 + 483 WP_030063552.1 hypothetical protein -
LN243_RS04585 960180..960359 + 180 WP_002504569.1 hypothetical protein -
LN243_RS04590 960344..960529 + 186 WP_001187008.1 hypothetical protein -
LN243_RS04595 960545..960829 + 285 WP_002504568.1 hypothetical protein -
LN243_RS04600 960826..960981 + 156 WP_002504567.1 transcriptional activator RinB -
LN243_RS04605 961007..961279 + 273 WP_002504566.1 hypothetical protein -
LN243_RS04610 961295..961837 + 543 WP_002504565.1 hypothetical protein -
LN243_RS04615 961830..962006 + 177 WP_002504564.1 hypothetical protein -
LN243_RS04620 962026..962247 + 222 WP_002504563.1 hypothetical protein -
LN243_RS04625 962247..962972 + 726 WP_010959229.1 metallophosphoesterase -
LN243_RS04630 962965..963282 + 318 WP_002504561.1 hypothetical protein -
LN243_RS04635 963282..963932 + 651 WP_002504560.1 hypothetical protein -
LN243_RS04640 963932..964450 + 519 WP_002504559.1 metallophosphoesterase -
LN243_RS04645 964613..964843 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
LN243_RS04650 964843..965238 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LN243_RS04655 965541..965732 + 192 WP_002504556.1 hypothetical protein -
LN243_RS04660 965716..965985 + 270 WP_000755772.1 hypothetical protein -
LN243_RS04665 966042..966536 + 495 WP_010959224.1 hypothetical protein -
LN243_RS04670 966540..967340 + 801 WP_000686449.1 metallophosphoesterase -
LN243_RS04675 967449..968171 + 723 WP_002504538.1 hypothetical protein -
LN243_RS04680 968277..968918 + 642 WP_002504537.1 hypothetical protein -
LN243_RS12620 968949..969083 - 135 WP_002504536.1 hypothetical protein -
LN243_RS04685 969166..969570 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 869795..996811 127016


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T224287 WP_002504557.1 NZ_CP086659:964843-965238 [Staphylococcus capitis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T224287 NZ_CP119980:4693996-4694307 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT224287 WP_002504558.1 NZ_CP086659:964613-964843 [Staphylococcus capitis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT224287 NZ_CP119980:4694308-4694598 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References