224286

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 841292..841815 Replicon chromosome
Accession NZ_CP086659
Organism Staphylococcus capitis strain XZ03

Toxin (Protein)


Gene name mazF Uniprot ID A0A1J4E8Y2
Locus tag LN243_RS04015 Protein ID WP_002435799.1
Coordinates 841459..841815 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1J4E747
Locus tag LN243_RS04010 Protein ID WP_002435513.1
Coordinates 841292..841462 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN243_RS03985 837119..837598 + 480 WP_023351370.1 PH domain-containing protein -
LN243_RS03990 837591..839090 + 1500 WP_030063298.1 PH domain-containing protein -
LN243_RS03995 839083..839583 + 501 WP_023351372.1 PH domain-containing protein -
LN243_RS04000 839632..839988 + 357 WP_002435510.1 holo-ACP synthase -
LN243_RS04005 840055..841203 + 1149 WP_023351373.1 alanine racemase -
LN243_RS04010 841292..841462 + 171 WP_002435513.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LN243_RS04015 841459..841815 + 357 WP_002435799.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LN243_RS04020 842194..843195 + 1002 WP_030063302.1 PP2C family protein-serine/threonine phosphatase -
LN243_RS04025 843297..843623 + 327 WP_002435753.1 anti-sigma factor antagonist -
LN243_RS04030 843625..844104 + 480 WP_002435518.1 anti-sigma B factor RsbW -
LN243_RS04035 844079..844849 + 771 WP_002435824.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13327.44 Da        Isoelectric Point: 9.8770

>T224286 WP_002435799.1 NZ_CP086659:841459-841815 [Staphylococcus capitis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDHQ

Download         Length: 357 bp

>T224286 NZ_CP119980:c4692763-4692452 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6263.87 Da        Isoelectric Point: 4.0121

>AT224286 WP_002435513.1 NZ_CP086659:841292-841462 [Staphylococcus capitis]
MLSFNQSRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNSKNE

Download         Length: 171 bp

>AT224286 NZ_CP119980:c4692455-4692009 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4E8Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E747

References