224285

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 830256..830770 Replicon chromosome
Accession NZ_CP086659
Organism Staphylococcus capitis strain XZ03

Toxin (Protein)


Gene name TsdT Uniprot ID A0A1J4E3P3
Locus tag LN243_RS03955 Protein ID WP_023351364.1
Coordinates 830564..830770 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1J4E888
Locus tag LN243_RS03950 Protein ID WP_002435858.1
Coordinates 830256..830549 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN243_RS03925 825414..826202 + 789 WP_023351361.1 hydroxyethylthiazole kinase -
LN243_RS03930 826209..826847 + 639 WP_023351362.1 thiamine phosphate synthase -
LN243_RS03935 826936..827808 + 873 WP_002435877.1 membrane protein insertase YidC -
LN243_RS03940 827867..828529 - 663 WP_023351363.1 HD domain-containing protein -
LN243_RS03945 828586..830070 - 1485 WP_002435854.1 cardiolipin synthase -
LN243_RS03950 830256..830549 + 294 WP_002435858.1 copper-sensing transcriptional repressor CsoR Antitoxin
LN243_RS03955 830564..830770 + 207 WP_023351364.1 hypothetical protein Toxin
LN243_RS03960 830907..831044 + 138 WP_002435861.1 Lmo0850 family protein -
LN243_RS03965 831100..832311 - 1212 WP_023351365.1 FtsW/RodA/SpoVE family cell cycle protein -
LN243_RS03970 832716..833786 + 1071 WP_002435813.1 D-alanine--D-alanine ligase -
LN243_RS03975 833802..835157 + 1356 WP_023351368.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7821.85 Da        Isoelectric Point: 4.2087

>T224285 WP_023351364.1 NZ_CP086659:830564-830770 [Staphylococcus capitis]
MENGIVYVANIETIEEENQLKTRLENMIGVEKVDIDSKVGEIKVLFETPANLNSIEKEVYDSGFRVRY

Download         Length: 207 bp

>T224285 NZ_CP119980:c4298117-4297632 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11065.56 Da        Isoelectric Point: 6.4776

>AT224285 WP_002435858.1 NZ_CP086659:830256-830549 [Staphylococcus capitis]
VTENETAHHSEQTKANLKSRLNRIEGQVRAINRMIEDDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMNKVNNGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT224285 NZ_CP119980:c4298392-4298105 [Salmonella enterica]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCAGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4E3P3

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E888

References