224282

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 740928..741452 Replicon chromosome
Accession NZ_CP086654
Organism Staphylococcus ratti strain CCM 9025

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LN051_RS03430 Protein ID WP_229293202.1
Coordinates 741099..741452 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LN051_RS03425 Protein ID WP_229293201.1
Coordinates 740928..741098 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN051_RS03400 (LN051_03400) 736429..736902 + 474 WP_229293196.1 PH domain-containing protein -
LN051_RS03405 (LN051_03405) 736892..738394 + 1503 WP_229293197.1 PH domain-containing protein -
LN051_RS03410 (LN051_03410) 738378..738899 + 522 WP_229293198.1 PH domain-containing protein -
LN051_RS03415 (LN051_03415) 739169..739519 + 351 WP_229293199.1 holo-ACP synthase -
LN051_RS03420 (LN051_03420) 739692..740840 + 1149 WP_229293200.1 alanine racemase -
LN051_RS03425 (LN051_03425) 740928..741098 + 171 WP_229293201.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LN051_RS03430 (LN051_03430) 741099..741452 + 354 WP_229293202.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LN051_RS03435 (LN051_03435) 741528..742514 + 987 WP_229293611.1 PP2C family protein-serine/threonine phosphatase -
LN051_RS03440 (LN051_03440) 742595..742921 + 327 WP_229293203.1 anti-sigma factor antagonist -
LN051_RS03445 (LN051_03445) 742924..743403 + 480 WP_229293204.1 anti-sigma B factor RsbW -
LN051_RS03450 (LN051_03450) 743378..744148 + 771 WP_229293205.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13081.23 Da        Isoelectric Point: 10.1660

>T224282 WP_229293202.1 NZ_CP086654:741099-741452 [Staphylococcus ratti]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDEKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

>T224282 NZ_CP119980:3488105-3488632 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTACAACGCCATGCACTACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACAATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6296.99 Da        Isoelectric Point: 4.2313

>AT224282 WP_229293201.1 NZ_CP086654:740928-741098 [Staphylococcus ratti]
MSTFNQTRVKSLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNESHLLSIHKDD

Download         Length: 171 bp

>AT224282 NZ_CP119980:3487818-3488108 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References