Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 727141..727667 Replicon chromosome
Accession NZ_CP086654
Organism Staphylococcus ratti strain CCM 9025

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag LN051_RS03360 Protein ID WP_229293189.1
Coordinates 727443..727667 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag LN051_RS03355 Protein ID WP_229293188.1
Coordinates 727141..727428 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN051_RS03330 (LN051_03330) 722526..723164 + 639 WP_229293184.1 thiamine phosphate synthase -
LN051_RS03335 (LN051_03335) 723253..724119 + 867 WP_229293185.1 membrane protein insertase YidC -
LN051_RS03340 (LN051_03340) 724498..724698 - 201 Protein_656 transposase -
LN051_RS03345 (LN051_03345) 724870..725502 - 633 WP_229293186.1 HD domain-containing protein -
LN051_RS03350 (LN051_03350) 725515..727005 - 1491 WP_229293187.1 cardiolipin synthase -
LN051_RS03355 (LN051_03355) 727141..727428 + 288 WP_229293188.1 copper-sensing transcriptional repressor CsoR Antitoxin
LN051_RS03360 (LN051_03360) 727443..727667 + 225 WP_229293189.1 heavy metal-associated domain-containing protein Toxin
LN051_RS03365 (LN051_03365) 727669..727872 + 204 WP_229293190.1 cation transporter -
LN051_RS03370 (LN051_03370) 727982..730171 + 2190 WP_229293191.1 heavy metal translocating P-type ATPase -
LN051_RS03375 (LN051_03375) 730256..730396 + 141 WP_086375151.1 Lmo0850 family protein -
LN051_RS03380 (LN051_03380) 730549..731763 - 1215 WP_229293192.1 FtsW/RodA/SpoVE family cell cycle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-66)

Antitoxin

Metal-sensitive transcriptional repressor

(12-90)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8546.84 Da        Isoelectric Point: 4.7063

>T224281 WP_229293189.1 NZ_CP086654:727443-727667 [Staphylococcus ratti]
MYKDIVFVEGIQSDLQKENLAQRLNQMIGVKEVTIDIERQSITLLYNTPVNLNTLEKEIYDTGYKVIRTEKGAI

Download         Length: 225 bp

>T224281 NZ_CP119980:c2487278-2487175 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11013.61 Da        Isoelectric Point: 6.0845

>AT224281 WP_229293188.1 NZ_CP086654:727141-727428 [Staphylococcus ratti]
MEERAHHSVEIKKNLTSRLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDYHMKGCITQKIEEGHETE
AMEELLVTFQKLLKD

Download         Length: 288 bp

>AT224281 NZ_CP119980:2487173-2487316 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References