Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4604890..4605485 Replicon chromosome
Accession NZ_CP086627
Organism Escherichia coli strain RIVM_C036569

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag LN356_RS22345 Protein ID WP_019842229.1
Coordinates 4604890..4605240 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag LN356_RS22350 Protein ID WP_001223213.1
Coordinates 4605234..4605485 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN356_RS22325 (4600220) 4600220..4601242 - 1023 WP_001550507.1 ABC transporter permease -
LN356_RS22330 (4601256) 4601256..4602758 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
LN356_RS22335 (4602890) 4602890..4603846 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LN356_RS22340 (4604156) 4604156..4604686 + 531 WP_000055075.1 inorganic diphosphatase -
LN356_RS22345 (4604890) 4604890..4605240 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
LN356_RS22350 (4605234) 4605234..4605485 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LN356_RS22355 (4605697) 4605697..4606038 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
LN356_RS22360 (4606041) 4606041..4609820 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T224275 WP_019842229.1 NZ_CP086627:c4605240-4604890 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T224275 NZ_CP119967:c2905491-2905264 [Pseudomonas sp. A34-9]
ATTGAACAACACAACTCCAACGCTTCAACATCGATGAAGAGTAAGGTTGGTGCAGCAGCACAGCGACTTTCGTCAATACC
TTATGGATACCGATCTGGCCGGGTACCCGGCACTCGCGAAATGGTGATTCCTCCAAACTATTTGTTGGTCTATCGAGTGA
ACGGGCGCATCAAAATACTGACGTTAGTCCACACCCGACAAAAATATCCTCGAATCTCATCAACATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT224275 WP_001223213.1 NZ_CP086627:c4605485-4605234 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT224275 NZ_CP119967:c2905732-2905538 [Pseudomonas sp. A34-9]
ATGAGCATATTGCTTTCCCCGTTTTATTCCGAGTTCGAATCCGAAGAAGAGGCCGAGAGCTACGATCGCTGGTTTCGTGC
CAAGGTGCAGGAGGCAATGGATGATCCTAGTCCGGGTATTCCCCATGAGGAAGCCATGGTACGGCTCGACCAATTATTAG
AAGAGAAACGCAAGAATCGACGCGCTGCCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References