Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | chpSB/PRK09812-ChpS |
Location | 4634529..4635124 | Replicon | chromosome |
Accession | NZ_CP086626 | ||
Organism | Escherichia coli strain RIVM_C037134 |
Toxin (Protein)
Gene name | chpB | Uniprot ID | A0A0V9NWK6 |
Locus tag | LN362_RS22590 | Protein ID | WP_019842229.1 |
Coordinates | 4634529..4634879 (-) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | chpS | Uniprot ID | L4JJX7 |
Locus tag | LN362_RS22595 | Protein ID | WP_001223213.1 |
Coordinates | 4634873..4635124 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LN362_RS22570 (4629859) | 4629859..4630881 | - | 1023 | WP_001550507.1 | ABC transporter permease | - |
LN362_RS22575 (4630895) | 4630895..4632397 | - | 1503 | WP_001550506.1 | sugar ABC transporter ATP-binding protein | - |
LN362_RS22580 (4632529) | 4632529..4633485 | - | 957 | WP_000265933.1 | galactofuranose ABC transporter substrate-binding protein YtfQ | - |
LN362_RS22585 (4633795) | 4633795..4634325 | + | 531 | WP_000055075.1 | inorganic diphosphatase | - |
LN362_RS22590 (4634529) | 4634529..4634879 | - | 351 | WP_019842229.1 | endoribonuclease toxin ChpB | Toxin |
LN362_RS22595 (4634873) | 4634873..4635124 | - | 252 | WP_001223213.1 | type II toxin-antitoxin system antitoxin ChpS | Antitoxin |
LN362_RS22600 (4635336) | 4635336..4635677 | - | 342 | WP_001550504.1 | gamma-glutamylcyclotransferase | - |
LN362_RS22605 (4635680) | 4635680..4639459 | - | 3780 | WP_001550503.1 | autotransporter assembly complex protein TamB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12483.44 Da Isoelectric Point: 5.6097
>T224248 WP_019842229.1 NZ_CP086626:c4634879-4634529 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE
Download Length: 351 bp
>T224248 NZ_CP119773:c4469699-4469322 [Dickeya fangzhongdai]
ATGAAATGGGTCAGTGCGCAAGACGTTATCGCCTTTCATGATCGCATCCTGCAGGTGTTGCCAGGAGTTGCTGGTATGGC
GGATCCTGGCCGGGCTGAAGCCTTGATTTATCGGGTGCAGAACCGGCTTTATTATGAAGATATGACGGATCTCTTTGAAC
TGGCAGCGACGTATTGGGTAACTGTTGCGCGGGGTCATATTTTTAATGATGGTAATAAGCGCACCGCCTTTTTCGTCACC
ATGGTATTTTTACGCCGCAATGGTGTATTAATTGCCGATAACGACAATTCGCTGGAAGAGCTTACCGTCAAGGCAGCAAC
GGGTGAATGCCAGGTGTCGGAACTCGCGGAGCAGTTAAGACTGCGGGTGGAAAAGTAA
ATGAAATGGGTCAGTGCGCAAGACGTTATCGCCTTTCATGATCGCATCCTGCAGGTGTTGCCAGGAGTTGCTGGTATGGC
GGATCCTGGCCGGGCTGAAGCCTTGATTTATCGGGTGCAGAACCGGCTTTATTATGAAGATATGACGGATCTCTTTGAAC
TGGCAGCGACGTATTGGGTAACTGTTGCGCGGGGTCATATTTTTAATGATGGTAATAAGCGCACCGCCTTTTTCGTCACC
ATGGTATTTTTACGCCGCAATGGTGTATTAATTGCCGATAACGACAATTCGCTGGAAGAGCTTACCGTCAAGGCAGCAAC
GGGTGAATGCCAGGTGTCGGAACTCGCGGAGCAGTTAAGACTGCGGGTGGAAAAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9331.64 Da Isoelectric Point: 4.6509
>AT224248 WP_001223213.1 NZ_CP086626:c4635124-4634873 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW
Download Length: 252 bp
>AT224248 NZ_CP119773:c4469917-4469696 [Dickeya fangzhongdai]
ATGAAAACGTACACCATTACTGAAGCCCGGCAAAACATTGCGGCGGTCATCGATACGGCGGCCCGCGGCGAGCCGGTGGA
AATTACGCGTCGAAATGGTACGTCGGCCGTACTCATCCCCAAGGCGGAGTTTGAGGCGTATCAGAACGCCAGACTAGACG
CTGAATTTGATTTCATCATGCAGCGCCACGGCCACACGGTTAAAGCGCTTGCCGACAGATGA
ATGAAAACGTACACCATTACTGAAGCCCGGCAAAACATTGCGGCGGTCATCGATACGGCGGCCCGCGGCGAGCCGGTGGA
AATTACGCGTCGAAATGGTACGTCGGCCGTACTCATCCCCAAGGCGGAGTTTGAGGCGTATCAGAACGCCAGACTAGACG
CTGAATTTGATTTCATCATGCAGCGCCACGGCCACACGGTTAAAGCGCTTGCCGACAGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0V9NWK6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | L4JJX7 |