Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4634529..4635124 Replicon chromosome
Accession NZ_CP086626
Organism Escherichia coli strain RIVM_C037134

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag LN362_RS22590 Protein ID WP_019842229.1
Coordinates 4634529..4634879 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag LN362_RS22595 Protein ID WP_001223213.1
Coordinates 4634873..4635124 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN362_RS22570 (4629859) 4629859..4630881 - 1023 WP_001550507.1 ABC transporter permease -
LN362_RS22575 (4630895) 4630895..4632397 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
LN362_RS22580 (4632529) 4632529..4633485 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LN362_RS22585 (4633795) 4633795..4634325 + 531 WP_000055075.1 inorganic diphosphatase -
LN362_RS22590 (4634529) 4634529..4634879 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
LN362_RS22595 (4634873) 4634873..4635124 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LN362_RS22600 (4635336) 4635336..4635677 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
LN362_RS22605 (4635680) 4635680..4639459 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-115)

Antitoxin

(6-49)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T224248 WP_019842229.1 NZ_CP086626:c4634879-4634529 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T224248 NZ_CP119773:c4469699-4469322 [Dickeya fangzhongdai]
ATGAAATGGGTCAGTGCGCAAGACGTTATCGCCTTTCATGATCGCATCCTGCAGGTGTTGCCAGGAGTTGCTGGTATGGC
GGATCCTGGCCGGGCTGAAGCCTTGATTTATCGGGTGCAGAACCGGCTTTATTATGAAGATATGACGGATCTCTTTGAAC
TGGCAGCGACGTATTGGGTAACTGTTGCGCGGGGTCATATTTTTAATGATGGTAATAAGCGCACCGCCTTTTTCGTCACC
ATGGTATTTTTACGCCGCAATGGTGTATTAATTGCCGATAACGACAATTCGCTGGAAGAGCTTACCGTCAAGGCAGCAAC
GGGTGAATGCCAGGTGTCGGAACTCGCGGAGCAGTTAAGACTGCGGGTGGAAAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT224248 WP_001223213.1 NZ_CP086626:c4635124-4634873 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT224248 NZ_CP119773:c4469917-4469696 [Dickeya fangzhongdai]
ATGAAAACGTACACCATTACTGAAGCCCGGCAAAACATTGCGGCGGTCATCGATACGGCGGCCCGCGGCGAGCCGGTGGA
AATTACGCGTCGAAATGGTACGTCGGCCGTACTCATCCCCAAGGCGGAGTTTGAGGCGTATCAGAACGCCAGACTAGACG
CTGAATTTGATTTCATCATGCAGCGCCACGGCCACACGGTTAAAGCGCTTGCCGACAGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6


Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References