Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 882193..883028 Replicon chromosome
Accession NZ_CP086626
Organism Escherichia coli strain RIVM_C037134

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0A1A9A5
Locus tag LN362_RS04230 Protein ID WP_001564063.1
Coordinates 882193..882570 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K5N986
Locus tag LN362_RS04235 Protein ID WP_021553056.1
Coordinates 882660..883028 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN362_RS04200 (877321) 877321..878469 - 1149 WP_000905920.1 capsule polysaccharide export inner-membrane protein KpsE -
LN362_RS04205 (878541) 878541..879524 - 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -
LN362_RS04210 (880334) 880334..880504 - 171 Protein_826 IS110 family transposase -
LN362_RS04215 (880847) 880847..881689 - 843 Protein_827 DUF4942 domain-containing protein -
LN362_RS04220 (881774) 881774..881968 - 195 WP_024181941.1 DUF957 domain-containing protein -
LN362_RS04225 (882047) 882047..882196 - 150 Protein_829 DUF5983 family protein -
LN362_RS04230 (882193) 882193..882570 - 378 WP_001564063.1 TA system toxin CbtA family protein Toxin
LN362_RS04235 (882660) 882660..883028 - 369 WP_021553056.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LN362_RS04240 (883191) 883191..883412 - 222 WP_000692345.1 DUF987 domain-containing protein -
LN362_RS04245 (883477) 883477..883953 - 477 WP_021553055.1 RadC family protein -
LN362_RS04250 (883969) 883969..884448 - 480 WP_001564060.1 antirestriction protein -
LN362_RS04255 (884714) 884714..885532 - 819 WP_001564059.1 DUF932 domain-containing protein -
LN362_RS04260 (885622) 885622..885855 - 234 WP_001278293.1 DUF905 family protein -
LN362_RS04265 (885861) 885861..886538 - 678 WP_001564058.1 hypothetical protein -
LN362_RS04270 (886689) 886689..887369 - 681 WP_001278649.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / kpsM / kpsT / ugd / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / papX 765165..960208 195043
- flank IS/Tn - - 880334..880489 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14094.09 Da        Isoelectric Point: 7.8045

>T224227 WP_001564063.1 NZ_CP086626:c882570-882193 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T224227 NZ_CP119754:c4764231-4763860 [Superficieibacter sp. HKU1]
ATGAAAGGAAAGGCGCTCTTTGATACCAATATCCTGATCGATCTGTTTAATGGCCATCGTGAGGCGATGTCAGCACTTGA
GGCTTATCCTCCACAGCATGCTATTAGTCTCGTTACCTGGATGGAAGTGATGGTCGGGGCGAAAAAATATCACCGGGAAC
ATCAAACGCGTATGGCGTTGAGCGCTTTTAATATTATTGGTATATCGCAGGATATTGCGGAACGGAGCGTAAATCTCAGG
CAAGAGTTCGGCTTAAAACTGCCGGACGCTATCATTCTCGCCACGGCTCAGCATCATCGCTATACGATGGTTACGCGGAA
TACAAAGGATTTCGCAGGCATACCCGGGGTCGTAACGCCTTATCAATTTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13615.39 Da        Isoelectric Point: 7.0264

>AT224227 WP_021553056.1 NZ_CP086626:c883028-882660 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT224227 NZ_CP119754:c4764482-4764228 [Superficieibacter sp. HKU1]
ATGAGCATGGTGGCAGGCATCGATATGGGCAGAATACTTCTTGATTTGTCTGATGACGTTATCAAGCGGCTTGACGATCT
TAAGCACCAGCGCGGCCTTCCGCGGGCTGAGTTGCTGCGTGAAGCGGTTGAAGAATACCTTGAAAGGCAGAATCAGGCTA
AAGCAGCCATCGCTAATGCGCTTGGGCTGTGGCAGGGTTTTGAAGAAGATGGTGTTGAGTTTGAAAGAGCGCTGCGCGAG
GAGTGGGAGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1A9A5

Antitoxin

Source ID Structure
AlphaFold DB A0A0K5N986

References