Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4658316..4658911 Replicon chromosome
Accession NZ_CP086625
Organism Escherichia coli strain RIVM_C037166

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag LN360_RS22770 Protein ID WP_019842229.1
Coordinates 4658316..4658666 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag LN360_RS22775 Protein ID WP_001223213.1
Coordinates 4658660..4658911 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN360_RS22750 (4653646) 4653646..4654668 - 1023 WP_001550507.1 ABC transporter permease -
LN360_RS22755 (4654682) 4654682..4656184 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
LN360_RS22760 (4656316) 4656316..4657272 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LN360_RS22765 (4657582) 4657582..4658112 + 531 WP_000055075.1 inorganic diphosphatase -
LN360_RS22770 (4658316) 4658316..4658666 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
LN360_RS22775 (4658660) 4658660..4658911 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LN360_RS22780 (4659123) 4659123..4659464 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
LN360_RS22785 (4659467) 4659467..4663246 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T224221 WP_019842229.1 NZ_CP086625:c4658666-4658316 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T224221 NZ_CP119754:c1303251-1303033 [Superficieibacter sp. HKU1]
ATGACTGACAAAGCATTAACCAAGACTGATTATTTGATGCGTTTGAGGCGCTGTCAGACAATCGACACGCTCGAACGCGT
CATTGAAAAGAACAAATATGAATTATCAGATAATGAGCTGGTTGTATTTTACTCAGCCGCCGATCATCGTCTTGCAGAAC
TGACCATGAATAAGCTTTACGATAAAATCCCACCTTCCGTATGGCAATTTATTCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT224221 WP_001223213.1 NZ_CP086625:c4658911-4658660 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT224221 NZ_CP119754:c1303653-1303279 [Superficieibacter sp. HKU1]
ATGGACGAATACTCGCCAAAAAGACACGATATCGCACAGCTTAAATTTCTCTGTGAAAACCTGTATCATGACTGCATTGC
CAACCTCGATGAGAGCAACCATGGCTGGGTCAACGATCCCACTTCGGCGATCAACCTCCAGTTAAATGAGCTTATCGAAC
ACATTGCTACCTTCGCGCTTAATTATAAGATTAAGTATAATGAAGATAATAATCTGGTTATGCAGATTGATGAATATCTG
GATGACACGTTTATGTTGTTCAGCAACTATGGCATTAGTACGCAGGATTTGCAGAAGTGGCGTAAATCCGGTAATAACCT
GTTTCACTGCTTTGTTAATGTGAGCCAGGCTAATCCGGCCAGACTCTCCTGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References