Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3949204..3949858 Replicon chromosome
Accession NC_009792
Organism Citrobacter koseri ATCC BAA-895

Toxin (Protein)


Gene name cptA Uniprot ID A0A078LNB4
Locus tag CKO_RS18175 Protein ID WP_024130921.1
Coordinates 3949204..3949611 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A078LG12
Locus tag CKO_RS18180 Protein ID WP_024130922.1
Coordinates 3949592..3949858 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKO_RS18155 3945106..3946839 - 1734 WP_012134996.1 single-stranded-DNA-specific exonuclease RecJ -
CKO_RS18160 3946845..3947558 - 714 WP_012134997.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CKO_RS18165 3947582..3948478 - 897 WP_012134998.1 site-specific tyrosine recombinase XerD -
CKO_RS18170 3948582..3949106 + 525 WP_012134999.1 flavodoxin FldB -
CKO_RS18175 3949204..3949611 - 408 WP_024130921.1 protein YgfX Toxin
CKO_RS18180 3949592..3949858 - 267 WP_024130922.1 FAD assembly factor SdhE Antitoxin
CKO_RS18185 3950115..3951095 + 981 WP_024130923.1 tRNA-modifying protein YgfZ -
CKO_RS18190 3951250..3951909 - 660 WP_012135004.1 hemolysin III family protein -
CKO_RS18195 3952071..3952382 - 312 WP_012135005.1 N(4)-acetylcytidine aminohydrolase -
CKO_RS18200 3952435..3953163 + 729 WP_012135006.1 MurR/RpiR family transcriptional regulator -
CKO_RS18205 3953284..3954717 + 1434 WP_012135007.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15888.77 Da        Isoelectric Point: 11.2845

>T22415 WP_024130921.1 NC_009792:c3949611-3949204 [Citrobacter koseri ATCC BAA-895]
VVLWQSDLRVSWRAQWLSLLIHGLVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRINTRQGEIKLLMDGRLRWQGQ
DWTIQGPPWMLKTGMMLRLRADSGKRQHLWLAADSMDDAEWRDLRRLMLQQATQG

Download         Length: 408 bp

>T22415 NC_009792:c3949611-3949204 [Citrobacter koseri ATCC BAA-895]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCACAATGGCTCTCTTTGCTCATTCATGGGCTTGTCGCCGC
ATTGGTTTTATTGATGCCCTGGCCATTGAGCTACACGCCGCTCTGGCTGATATTGCTTTCGCTGGTGGTGTTCGACTGTG
TGCGCAGTCAGCGGCGGATTAATACCCGGCAGGGCGAAATTAAACTGCTGATGGATGGGCGTTTACGTTGGCAAGGGCAA
GACTGGACGATTCAGGGGCCGCCTTGGATGCTTAAAACCGGCATGATGCTGCGTTTGCGCGCCGACAGCGGGAAGCGTCA
GCATTTGTGGCTGGCGGCAGACAGCATGGATGACGCCGAGTGGCGGGATTTACGGCGGTTAATGTTGCAACAGGCGACGC
AGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10476.00 Da        Isoelectric Point: 4.8836

>AT22415 WP_024130922.1 NC_009792:c3949858-3949592 [Citrobacter koseri ATCC BAA-895]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKCIFVRLLECDDPDLFNWLMNHGKPGDAELEQMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT22415 NC_009792:c3949858-3949592 [Citrobacter koseri ATCC BAA-895]
ATGGATATTAATAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTCGACATTTCTATCATGCCGTT
TTTCGAACATGAGTACGATAACTTAAGCGATGAAGAAAAATGCATCTTTGTTCGTTTGCTGGAATGCGACGATCCTGATT
TATTTAACTGGTTGATGAACCACGGTAAACCGGGGGATGCAGAACTGGAACAAATGGTGAAACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A078LNB4

Antitoxin

Source ID Structure
AlphaFold DB A0A078LG12

References