Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2869351..2869989 Replicon chromosome
Accession NZ_CP086622
Organism Escherichia coli strain RIVM_C037884

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag LN352_RS14110 Protein ID WP_000813795.1
Coordinates 2869813..2869989 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LN352_RS14105 Protein ID WP_076797675.1
Coordinates 2869351..2869767 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN352_RS14085 (2864503) 2864503..2865444 - 942 WP_001251315.1 ABC transporter permease -
LN352_RS14090 (2865445) 2865445..2866458 - 1014 WP_001551095.1 ABC transporter ATP-binding protein -
LN352_RS14095 (2866476) 2866476..2867621 - 1146 WP_001551094.1 ABC transporter substrate-binding protein -
LN352_RS14100 (2867866) 2867866..2869272 - 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
LN352_RS14105 (2869351) 2869351..2869767 - 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LN352_RS14110 (2869813) 2869813..2869989 - 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LN352_RS14115 (2870211) 2870211..2870441 + 231 WP_023910283.1 YncJ family protein -
LN352_RS14120 (2870533) 2870533..2872494 - 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LN352_RS14125 (2872567) 2872567..2873103 - 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
LN352_RS14130 (2873195) 2873195..2874367 + 1173 WP_001551088.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T224133 WP_000813795.1 NZ_CP086622:c2869989-2869813 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T224133 NZ_CP119734:c1229008-1228901 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT224133 WP_076797675.1 NZ_CP086622:c2869767-2869351 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT224133 NZ_CP119734:1229061-1229122 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References